Clinical Roundup

Antibody-drug conjugate targeting CEACAM5 shows activity in advanced CRC in phase I study preliminary data

Preliminary data from a phase I study evaluating the novel antibody-drug conjugate M9140 demonstrated encouraging activity in heavily pretreated patients with advanced colorectal cancer. The study was presented by principal investigator Scott Kopetz, professor of gastrointestinal medical oncology and associate vice president for Translational Integration at MD Anderson, at the 2024 American Society of Clinical Oncology Annual Meeting.
Clinical Roundup

USP1 inhibitor combination shows manageable safety profile, anti-tumor activity in metastatic solid tumors in phase I study preliminary data

Preliminary data from the first-in-human phase I trial of RO7623066—a first-in-class inhibitor of ubiquitin-specific peptidase 1—show a promising safety profile as a single agent and signs of early anti-tumor activity for patients with advanced solid tumors. The data were presented by Timothy Yap, professor of investigational cancer therapeutics and vice president and head of clinical development in MD Anderson’s Therapeutics Discovery division, at the 2024 American Society of Clinical Oncology Annual Meeting.
Cullen Taniguchi, radiation oncologist at MD Anderson, dies at 47
FreeObituary

Cullen Taniguchi, radiation oncologist at MD Anderson, dies at 47

We unexpectedly lost a dear friend and colleague, Dr. Cullen Taniguchi, in mid-November. Dr. Taniguchi was an exceptional and compassionate clinician, brilliant scientist, and nurturing mentor. Above all, he was a dedicated and loving husband, father, son, and brother. We deeply mourn his loss, but we forever cherish the memories and indelible legacy that he leaves with us.