A. Lindo Patterson came to Fox Chase Cancer Center in 1949, when it was still known as the Institute for Cancer Research.
During his time at the institute, he played a major role in running an X-ray structure analysis group and mentoring some of the best young scientists in the field.
“I came to Fox Chase in 1956 because of his excellent science. I considered Patterson to be a role model, particularly because of his willingness to hire women and his dedication to precise studies,” said Jenny Glusker, who started at Fox Chase as a research fellow and is now a professor emerita.
An obituary in the journal Acta Crystallographica described Patterson as possessing “a rare combination of a keen mind, a lively humor, and a gentle disposition.”
Patterson accomplished a great deal at Fox Chase, but he had already made great strides in the scientific community before his arrival at the center. One of his key accomplishments was the groundbreaking Patterson function, an equation in X-ray crystallography that helps determine the three-dimensional atomic structure and characteristics of molecules, information which helped researchers develop new and better drugs.
“He was a very well-known scientist, and it was assumed he’d win a Nobel Prize because he figured out how to take the diffraction pattern of a crystal and work out what the arrangement of atoms in it was. That led people to finally be able to understand how you get pictures of how molecules are arranged,” said Glusker. At that time, most scientists used his formula if they were trying to determine molecular structure by X-ray diffraction.
He never did win the Nobel Prize, however, because of his early death, Glusker said. But he had a storied career nonetheless.
It was assumed he’d win a Nobel Prize because he figured out how to take the diffraction pattern of a crystal and work out what the arrangement of atoms in it was. That led people to finally be able to understand how you get pictures of how molecules are arranged.
Jenny Glusker
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