The 16th Annual Gateway Hospital Medicine Conference: “Care of the Hospitalized Patient” is planned and implemented inter-professionally by adult and pediatric physicians and nurse practitioners (NPs). This conference is designed for hospitalists, subspecialty physicians, and advanced practice providers and may be of interest to physician associates and pharmacists. “Care of the Hospitalized Patient” has been an annual Continuing Medical Education (CME) conference that has grown in popularity and attendance since it began in 2005. Paused during the COVID-19 pandemic, it is now expanded and renewed for healthcare clinicians throughout the Midwest, South, and beyond. This two-day CME course will provide education through evidence-based lectures, case-based interactive presentations, and breakout sessions. The Gateway Hospital Medicine Conference will highlight best practices in the specialty of hospital medicine for adult and pediatric hospitalists and techniques to optimize care for the hospitalized patient. The goal of this activity is to enhance knowledge, skills, and patient care.