AstraZeneca to acquire TeneoTwo and its clinical-stage T-cell engager, TNB-486

Prasad’s rule by fiat spilled into accelerated approvals in hematology and oncology
Atara Bio’s Cokey Nguyen: Normally, FDA wants to help us succeed. Now, “we’re getting new guidance at the last minute and it’s not helping.”

On Jan. 9, Pierre Fabre Pharmaceuticals received a “complete response letter” from FDA: its application for the T-cell therapy tabelecleucel (Ebvallo) was getting a hard No.

March 13, 2026

Vol.52 No.10

By Jacquelyn Cobb

Cancer History Project

The murder of Alexei Navalny is part of Russia’s macabre fascination with poisons
A gallop through history of poisonings—from hemlock, to mustard gas, to Polonium-210, to dart frog poison

Poisoning one’s political rivals has a long history. In 399 B.C., an Athenian court found Socrates guilty of “impiety and the corruption of youth” and ordered him to drink a fatal dose of hemlock.

Long-term analysis suggests follicular lymphoma can be cured, Fred Hutch study finds

Follicular lymphoma, a common and usually slow-growing type of non-Hodgkin lymphoma, has long been deemed incurable: Though the disease responds well to initial treatment, oncologists tell patients to expect it to come back. The results from a 15-year follow-up analysis of clinical trial patients with follicular lymphoma could upend that prediction.

March 13, 2026

Vol.52 No.10

Clinical Roundup

Phase I data released from study of Lymphir dosing prior to commercial CAR T therapy in high‑risk diffuse large b‑cell lymphoma

Citius Oncology announced positive topline safety and efficacy results from an investigator‑initiated phase I trial evaluating Lymphir (E7777, denileukin diftitox‑cxdl) administered prior to commercial CD19‑directed CAR T therapy in patients with high‑risk relapsed or refractory diffuse large B‑cell lymphoma.

March 13, 2026

Vol.52 No.10

Clinical Roundup

Follicular lymphoma may be curable with chemoimmunotherapy combo, data from 15-year trial suggests

Long-term data on patients treated with a standard chemoimmunotherapy combination show relapse rates dropped over time and 70% of patients were still alive 15 years later, with an overall cure rate estimated at 42% of patients treated, according to a study led by scientists at SWOG, Fred Hutch Cancer Center, and the University of Rochester Medical Center.

February 27, 2026

Vol.52 No.08

Cancer Policy

Bayer agrees to $7.25B settlement over lawsuits alleging Roundup weedkiller caused cancer

Bayer, the owner of the herbicide Roundup, offered $7.25 billion to settle thousands of lawsuits alleging that the product is responsible for causing cases of Non-Hodgkin lymphoma.

February 20, 2026

Vol.52 No.07

By Sara Willa Ernst

AstraZeneca to acquire TeneoTwo and its clinical-stage T-cell engager, TNB-486

YOU MAY BE INTERESTED IN

Prasad’s rule by fiat spilled into accelerated approvals in hematology and oncology
Atara Bio’s Cokey Nguyen: Normally, FDA wants to help us succeed. Now, “we’re getting new guidance at the last minute and it’s not helping.”

The murder of Alexei Navalny is part of Russia’s macabre fascination with poisons
A gallop through history of poisonings—from hemlock, to mustard gas, to Polonium-210, to dart frog poison

Long-term analysis suggests follicular lymphoma can be cured, Fred Hutch study finds

Phase I data released from study of Lymphir dosing prior to commercial CAR T therapy in high‑risk diffuse large b‑cell lymphoma

Follicular lymphoma may be curable with chemoimmunotherapy combo, data from 15-year trial suggests

Bayer agrees to $7.25B settlement over lawsuits alleging Roundup weedkiller caused cancer

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AstraZeneca to acquire TeneoTwo and its clinical-stage T-cell engager, TNB-486

YOU MAY BE INTERESTED IN

Prasad’s rule by fiat spilled into accelerated approvals in hematology and oncologyAtara Bio’s Cokey Nguyen: Normally, FDA wants to help us succeed. Now, “we’re getting new guidance at the last minute and it’s not helping.”

The murder of Alexei Navalny is part of Russia’s macabre fascination with poisonsA gallop through history of poisonings—from hemlock, to mustard gas, to Polonium-210, to dart frog poison

Long-term analysis suggests follicular lymphoma can be cured, Fred Hutch study finds

Phase I data released from study of Lymphir dosing prior to commercial CAR T therapy in high‑risk diffuse large b‑cell lymphoma

Follicular lymphoma may be curable with chemoimmunotherapy combo, data from 15-year trial suggests

Bayer agrees to $7.25B settlement over lawsuits alleging Roundup weedkiller caused cancer

Never miss an issue!

Login

Prasad’s rule by fiat spilled into accelerated approvals in hematology and oncology
Atara Bio’s Cokey Nguyen: Normally, FDA wants to help us succeed. Now, “we’re getting new guidance at the last minute and it’s not helping.”

The murder of Alexei Navalny is part of Russia’s macabre fascination with poisons
A gallop through history of poisonings—from hemlock, to mustard gas, to Polonium-210, to dart frog poison