John Mark Cleland died peacefully on Feb. 7, 2022, in Indianapolis. Some people reading this headline will have little or no idea who John Cleland was. However, if you are a medical or urological oncologist, you should. John Cleland was the first man whose metastatic testicular cancer was cured with combination chemotherapy containing cisplatin.
Obviously, the field of immune-oncology has been one of the great success stories in our field over the last five years, based on our molecular understanding of the mechanisms of immune tolerance (or checkpoints) and how to disrupt that. Not only has ASCO declared Checkpoint Inhibition (as well as cellular-based immunotherapy) the “Advance of the Year,” the Nobel Committee awarded this year's Prize to Drs. Allison and Honjo for their fabulous observations that led to these great breakthroughs.