Factors outside CAR T-cell therapy are associated with increased risk of secondary cancers after the treatment, meta-analysis shows

Subgroup analysis suggests risk of secondary cancers after CAR T-cell therapy is similar to risk after other therapies

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A meta-analysis of 25 studies—totaling over 5,000 participants—focused on a question that has been troubling patients, physicians, and regulators: Does treatment with CAR T-cell therapy contribute to the development of secondary cancers?

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McKenzie Prillaman
McKenzie Prillaman
Reporter
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Patients with relapsed or refractory CD19-positive B-cell acute lymphoblastic leukemia who were treated with the novel anti-CD19 chimeric antigen receptor T-cell therapy, obecabtagene autoleucel, experienced high response rates and most did not need a subsequent stem cell transplant, according to results from the phase Ib/II FELIX trial co-led by researchers at the University of Texas MD Anderson Cancer Center.
McKenzie Prillaman
McKenzie Prillaman
Reporter

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