HER3-targeted antibody-drug conjugate shows promise for treatment-resistant solid tumors

Lou Weisbach tells us about his plan to raise $750 billion for the American Center for Cures

For nearly 25 years, business executive Lou Weisbach and urologist Richard J. Boxer have argued that finding the money to finance the cures for devastating diseases is not as difficult as it appears. To start finding the cures, the U.S. Department of the Treasury needs to issue some bonds—$750 billion worth. Next, you hire CEOs—one...

June 20, 2025

Vol.51 No.24

By Otis W. Brawley and Paul Goldberg

Clinical Roundup

Study of retifanlimab in squamous cell carcinoma meets primary endpoint of PFS

Primary results from the phase III POD1UM-303/InterAACT 2 trial of retifanlimab (Zynyz), a humanized monoclonal antibody targeting programmed death receptor-1, in combination with carboplatin and paclitaxel (platinum-based chemotherapy) in adult patients with inoperable locally recurrent or metastatic squamous cell carcinoma of the anal cancer who have not been previously treated with systemic chemotherapy, were published in The Lancet.

June 20, 2025

Vol.51 No.24

Cancer Policy

In “Bethesda Declaration,” NIH employees, Nobel laureates say Bhattacharya is favoring politics over U.S. science, health

NIH Director Jayanta Bhattacharya “prioritizes political momentum over human safety and faithful stewardship of public resources,” a group of Nobel laureates and over 300 NIH employees wrote in a letter.

Samir S. Taneja named head of Northwell Health’s urology service line

Samir S. Taneja was selected to lead Northwell Health’s urology service line. He was appointed senior vice president, Northwell’s system chair of urology, and chair of the Smith Institute for Urology at Northwell Health.

June 13, 2025

Vol.51 No.23

Clinical Roundup

Mail-in self-collection HPV tests boost cervical cancer screening rates

Mail-in self-collection tests for human papillomavirus more than doubled cervical cancer screening participation among never- and under-screened U.S. women, according to a first-of-its-kind study from researchers at the University of Texas MD Anderson Cancer Center.

June 13, 2025

Vol.51 No.23

Clinical Roundup

Children’s Research Institute scientists uncover novel mechanism that helps tumors withstand stress

Scientists have discovered tumors can tap a nontraditional pathway to acquire lipoproteins—molecules that transport fat in blood—which enriches cancer cells with an antioxidant shield to survive stress, according to new research from Children’s Medical Center Research Institute at UT Southwestern published in Nature.

June 13, 2025

Vol.51 No.23

HER3-targeted antibody-drug conjugate shows promise for treatment-resistant solid tumors

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Lou Weisbach tells us about his plan to raise $750 billion for the American Center for Cures

Study of retifanlimab in squamous cell carcinoma meets primary endpoint of PFS

In “Bethesda Declaration,” NIH employees, Nobel laureates say Bhattacharya is favoring politics over U.S. science, health

Samir S. Taneja named head of Northwell Health’s urology service line

Mail-in self-collection HPV tests boost cervical cancer screening rates

Children’s Research Institute scientists uncover novel mechanism that helps tumors withstand stress

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