Neoadjuvant immunotherapy + chemo regimen significantly improves long-term survival in NSCLC

Vinai Gondi, Bridget Koontz, Priya Rastogi, Lisa Lenrow named to NRG Oncology committee leadership

Vinai GondiBridget KoontzPriya RastogiLisa LenrowNRG Oncology, an NCI National Clinical Trials Network group focused on improving outcomes for adults with cancer through multi-center clinical research, recently announced changes in leadership across multiple committees.

October 31, 2025

Vol.51 No.40

Clinical Roundup

Ozekibart improves PFS in chondrosarcoma, registrational phase II trial shows

Positive topline results from the registrational ChonDRAgon study investigating ozekibart (INBRX-109) as a single agent versus placebo in patients with advanced or metastatic, unresectable chondrosarcoma were recently reported.

October 31, 2025

Vol.51 No.40

Clinical Roundup

Researchers develop technique to track chemotherapy drug inside cells

Scientists face limitations in determining the results of drug effectiveness, as well as ensuring even distribution among all cancer cells because of the highly compact nature of tumors. Researchers are working to change that by giving chemotherapy drugs a kind of chemical “signal” to track them inside cells.

October 31, 2025

Vol.51 No.40

Clinical Roundup

Enhancing the body’s “first responder” cells may boost immune therapy, Mayo study finds

Mayo Clinic researchers have identified a specific immune cell that can be targeted to give a boost to standard immunotherapies for cancer. Two research teams, working collaboratively but using distinct approaches, found that “first-responder” immune cells known as myeloid cells can be manipulated to enhance the activity of tumor-killing T cells.

October 31, 2025

Vol.51 No.40

Drugs & Targets

EC approves Keytruda combination for a head-and-neck indication

The European Commission approved Keytruda (pembrolizumab), an anti-PD-1 therapy, as a monotherapy for the treatment of resectable locally advanced head-and-neck squamous cell carcinoma as neoadjuvant treatment, continued as adjuvant treatment in combination with radiation therapy with or without concomitant cisplatin and then as monotherapy in adults whose tumors express PD-L1 with a Combined Positive Score ≥1.

October 31, 2025

Vol.51 No.40

Clinical Trials & Tribulations

Experts warn that loss of carcinogen surveillance threatens to increase cancer incidence

Testing of chemicals for potential cancer causation (carcinogenesis) has long been a successful disease-prevention initiative of the highest priority.

October 24, 2025

Vol.51 No.39

By David M. DeMarini, Rosalie Elespuru, Miriam C. Poirier and Errol Zeiger

Neoadjuvant immunotherapy + chemo regimen significantly improves long-term survival in NSCLC

YOU MAY BE INTERESTED IN

Vinai Gondi, Bridget Koontz, Priya Rastogi, Lisa Lenrow named to NRG Oncology committee leadership

Ozekibart improves PFS in chondrosarcoma, registrational phase II trial shows

Researchers develop technique to track chemotherapy drug inside cells

Enhancing the body’s “first responder” cells may boost immune therapy, Mayo study finds

EC approves Keytruda combination for a head-and-neck indication

Experts warn that loss of carcinogen surveillance threatens to increase cancer incidence

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