City of Hope and TGen research reveals potential cause of aggressive leukemia

How City of Hope is using AI to improve surgical outcomes

With recent leaps in artificial intelligence, there is major potential to turn computing advances into gains for human health.

Building a nationally integrated cancer research and treatment network

Cancer care is at an inflection point. The traditional boundaries between academic and community oncology are dissolving, requiring a reimagined approach to patient care and clinical research. At City of Hope, we are implementing a national model that integrates breakthrough research with accessible, advanced treatment across diverse geographic regions.

Investigational Orca-T treatment for hematologic malignancies meets primary endpoint in phase III trial

Orca Bio, a late-stage biotechnology company, on March 17 announced results from the pivotal phase III Precision-T study of Orca-T, its lead investigational allogeneic T-cell immunotherapy, in patients with acute myeloid leukemia, acute lymphoblastic leukemia, high-risk myelodysplastic syndrome and mixed-phenotype acute leukemia. Orca-T is manufactured using highly purified regulatory T-cells, hematopoietic stem cells and conventional T-cells derived from peripheral blood from either related or unrelated matched donors.

March 28, 2025

Vol.51 No.12

Clinical Roundup

Mutated cells can persist for years without becoming cancer and need an inflammatory “push” for malignancy to occur, COH study shows

Researchers at City of Hope have found that cell mutations are necessary but not always sufficient for tumors to form. Instead, they suggest that additional risk factors that promote tumor growth, like chronic inflammation, are a key trigger for tumor formation.

March 28, 2025

Vol.51 No.12

Sponsored

Targeting the thymus to rejuvenate immune function

The thymus gland, in many ways, remains a mystery. The thymic regeneration division of the laboratory of Marcel van den Brink, president of City of Hope Los Angeles and City of Hope National Medical Center, is trying to tease out its secrets.

Accelerating translational research in leukemia: The City of Hope approach

As a physician-scientist, I navigate the intersection of laboratory research and clinical care every day. At City of Hope, our mission is to rapidly translate groundbreaking discoveries into effective treatments for patients with hematologic malignancies, particularly acute leukemias. This is possible due to a unique combination of infrastructure and culture combined with an unwavering sense of urgency.

March 14, 2025

Vol.51 No.10

By Guido Marcucci