NYU study: Alzheimer’s protein protects metastasized melanoma cells in the brain

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Researchers from NYU Grossman School of Medicine and NYU’s Laura and Isaac Perlmutter Cancer Center found that amyloid beta, a protein known to build-up in the brains of Alzheimer’s patients, helps melanoma cells thrive when they have spread to the brain. The study authors focused on melanoma because it metastasizes to the brain in 40% of patients with stage IV disease.

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Roger Lo, professor of medicine, dermatology, and molecular and medical pharmacology and investigator at the UCLA Health Jonsson Comprehensive Cancer Center, was awarded a $2 million grant from NIH to investigate innovative strategies to prevent drug resistance in melanoma treatment and improve the effectiveness of MAPK inhibitors, a common treatment for patients with melanomas that carry the BRAFV600 mutation.

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