Relatlimab + Opdivo improves PFS in metastatic melanoma

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In patients with untreated, advanced melanoma, the combination of immune checkpoint inhibitors relatlimab and Opdivo (nivolumab) doubled the progression-free survival benefit compared to Opdivo alone, with a manageable safety profile, according to results of the phase II/III  RELATIVITY-047 clinical trial reported by The University of Texas MD Anderson Cancer Center. 

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Roger Lo, professor of medicine, dermatology, and molecular and medical pharmacology and investigator at the UCLA Health Jonsson Comprehensive Cancer Center, was awarded a $2 million grant from NIH to investigate innovative strategies to prevent drug resistance in melanoma treatment and improve the effectiveness of MAPK inhibitors, a common treatment for patients with melanomas that carry the BRAFV600 mutation.

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