Phase III GY004 for Cediranib and Lynparza doesn’t meet PFS endpoint in ovarian cancer indication

The phase III GY004 trial examining primarily the efficacy and safety of investigational medicine cediranib in combination with Lynparza versus platinum-based chemotherapy in patients with platinum-sensitive relapsed ovarian cancer failed to meet its primary endpoint of progression-free survival.

The trial was conducted by NRG Oncology. AstraZeneca and Merck sponsor the trial.

The trial did not meet the primary endpoint in the intent-to-treat population of a statistically significant improvement in progression-free survival with cediranib in combination with Lynparza vs. platinum-based chemotherapy.

Cediranib is an investigational oral vascular endothelial growth factor receptor inhibitor.

“Despite these disappointing results, we remain committed to expanding on the benefits already demonstrated with Lynparza for patients with advanced ovarian cancer,” Jose Baselga, executive vice president of oncology R&D, AstraZeneca, said in a statement.

The safety and tolerability profiles observed in GY004 were generally consistent with those known for each medicine.

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Phase III GY004 for Cediranib and Lynparza doesn’t meet PFS endpoint in ovarian cancer indication

YOU MAY BE INTERESTED IN

Supreme Court removes “Chevron deference,” threatening drug regulation, health coverage, delivery of cancer care

Georgetown’s Zachary Baron on the post-Chevron era: We need guardrails about when agency expertise should be cast aside

A modest proposal from a former FDA commissioner: Add antidepressants to the nation’s water supplyWarning: This is not a public health recommendation. Do not implement.

At Lung SPORE Workshop, experts reflect on the significance of discovery of EGFR mutations two decades ago

The early days of EGFR: Herbst, Haber, Meyerson, Pao, Sequist present at Yale SPORE workshop

Elizabeth Comen joins NYU Langone Health’s Perlmutter Cancer Center

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A modest proposal from a former FDA commissioner: Add antidepressants to the nation’s water supply
Warning: This is not a public health recommendation. Do not implement.