Results from the phase III stage of a clinical trial demonstrated that acupuncture-like, transcutaneous electrical nerve stimulation may be equally effective as pilocarpine, the current prescription medication in a pill, to treat radiation-induced dry mouth.
A phase III trial of adjuvant Prolia (denosumab) therapy in postmenopausal women with early hormone receptor positive breast cancer receiving aromatase inhibitor therapy met its primary endpoint of time from randomization to first clinical fracture (HR=0.5, 95 percent CI 0.39-0.65, p<0.0001).
Interim findings from an ongoing phase II clinical study of PEGPH20 showed a doubling of progression-free survival and an improvement trend in overall survival in metastatic pancreatic cancer patients with high levels of hyaluronan.
Progression-free survival data from a phase II study evaluating Afinitor (everolimus) as a second-line therapy in advanced renal cell carcinoma were presented at the annual meeting of the American Society of Clinical Oncology in Chicago.
Data from PERSIST-1, a phase III trial examining pacritinib for the treatment of myelofibrosis, showed that compared to best available therapy (exclusive of a JAK inhibitor), pacritinib therapy resulted in a significantly higher proportion of patients with spleen volume reduction and control of disease-related symptoms.
Results from a retrospective analysis of the phase III SYNERGY trial showed a benefit with custirsen therapy in men with metastatic castrate-resistant prostate cancer who had a poor prognosis.
Overall survival results from the LUX-Lung 8 trial comparing two EGFR-directed treatments, Gilotrif (afatinib) and Tarceva (erlotinib), in patients with advanced squamous cell carcinoma of the lung progressing after treatment with first-line chemotherapy, demonstrated that treatment with Gilotrif significantly reduced the risk of death by 19 percent, extending the survival of patients to a median of 7.9 months compared to 6.8 months on Tarceva.
Data from the phase III COMBI-d study showed a significant survival benefit for patients with BRAF V600E/K mutation-positive metastatic melanoma when treated with the combination of Tafinlar and Mekinist compared to Tafinlar alone.
Patients with previously treated chronic lymphocytic leukemia or small lymphocytic lymphoma that received Imbruvica (ibrutinib) in combination with bendamustine and rituximab experienced an 80 percent reduction in the risk of progression or death when compared to patients receiving bendamustine, rituximab and placebo in a phase III trial.
FDA granted an Orphan Drug Designation to Reolysin for the treatment of malignant glioma.
