MD Anderson researchers, led by Renata Ferrarotto, conducted a phase II trial evaluating the combination of the VEGFR inhibitor axitinib plus the PD-L1 inhibitor avelumab in 28 patients with progressive recurrent or metastatic adenoid cystic carcinoma, a rare salivary gland cancer for which there are limited treatment options.
A novel approach to administer intrathecal immunotherapy (directly into the spinal fluid) and intravenous immunotherapy was safe and improved survival in a subset of patients with leptomeningeal disease from metastatic melanoma, according to interim analyses of a phase I/Ib trial led by researchers at MD Anderson Cancer Center.
Cancer and its treatment can accelerate the rate of aging because they both destabilize and damage biological systems in the body. Research published in Cancer, a journal of the American Cancer Society, found that African American cancer survivors who reported high levels of discrimination exhibited greater aging and frailty than those reporting lower levels of discrimination.
Investigators at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine found that treatment outcomes for patients with malignant pleural mesothelioma, a rare cancer commonly known as mesothelioma, are often affected by social determinants of health and that overall survival rates could be improved by addressing these health disparities and improving access to specialized care.
Researchers have shown for the first time exactly how immature neutrophils—white blood cells that are an important part of the immune system—are hijacked by pancreatic cancers to drive immunosuppression and treatment resistance. The study, led by investigators at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, was published in Cancer Discovery.
In a study published in Blood, scientists from the USC Stem Cell laboratory of Rong Lu discovered a mechanism that linked a leukemic mutation to varying potentials for disease development—a discovery which could eventually lead to a way to identify patients with the mutation who are most at risk.
Yale Medicine physicians are using robotic bronchoscopy instead of traditional bronchoscopy for lung cancer diagnosis. Robotic bronchoscopy allows them to better reach smaller parts of the lungs. During a robotic bronchoscopy, the doctor uses a controller at a console to operate a robotic arm, which then guides the bronchoscope’s thin, flexible tube through the airways.
In a study of more than 1,100 people with COVID-19 undergoing treatment for cancer, researchers found lower COVID-19 vaccination rates among patients with comorbidities, metastatic solid tumors or non-B-cell hematologic malignancies, and those living in areas with lower education attainment and higher levels of unemployment.
Galera Therapeutics Inc. presented a supplemental net treatment benefit analysis of phase III ROMAN results at the 10th European Congress on Head and Neck Oncology, which took place March 8-11.
In a phase II trial led by researchers from MD Anderson Cancer Center, adding ipilimumab to a neoadjuvant combination of nivolumab plus platinum-based chemotherapy resulted in a major pathologic response in half of all treated patients with early-stage, resectable non-small cell lung cancer.
