According to the results of the ZUMA-7 clinical trial, the CAR T-cell therapy Yescarta (axicabtagene ciloleucel) is significantly more effective than the current standard of care in treating people with large B-cell lymphoma who relapse after the first line of treatment.
In patients with untreated, advanced melanoma, the combination of immune checkpoint inhibitors relatlimab and Opdivo (nivolumab) doubled the progression-free survival benefit compared to Opdivo alone, with a manageable safety profile, according to results of the phase II/III RELATIVITY-047 clinical trial reported by The University of Texas MD Anderson Cancer Center.
Patients with melanoma who reported eating more fiber-rich foods when they began immunotherapy survived longer without cancer growth than patients with insufficient dietary fiber intake, according to research from The University of Texas MD Anderson Cancer Center.
A phase II trial investigating the anti-TIGIT cancer immunotherapy tiragolumab plus Tecentriq (atezolizumab) compared with Tecentriq alone as a first-line treatment for people with PD-L1-positive metastatic non-small cell lung cancer showed that the combination improved progression-free survival.
A University of Toronto-led study found that only 59% of oncology clinical trials studied provided adequately-defined rules for censoring.
Researchers at Penn Medicine have illuminated key molecular details of the T-cell exhaustion process, identifying a specific strategy for making chimeric antigen receptor (CAR) T cell-therapy more effective against solid tumors.
A study led by Susan G. Komen Brinker Award winner Carlos Caldas found that there may be a way to predict treatment response in breast cancer patients even before treatment begins. Results will be presented at the 2021 San Antonio Breast Cancer Symposium Dec. 7-10.
The use of multigene sequencing as a therapeutic decision tool improved outcomes for patients with metastatic breast cancer when the genomic alterations identified were ranked in the I/II tiers of the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT), according to results from the SAFIR02-BREAST trial.
The investigational oral selective estrogen receptor degrader elacestrant significantly decreased the risk of death or disease progression and increased progression-free survival compared with standard-of-care endocrine therapy for postmenopausal patients with estrogen receptor (ER)-positive/HER2-negative metastatic breast cancers that progressed on prior endocrine and targeted therapies, according to results from the phase III EMERALD trial.
Among patients with hormone receptor-positive breast cancer treated with an aromatase inhibitor plus Ibrance (palbociclib), those who displayed a rising ESR1 mutation detected in their blood before disease progression doubled their median progression-free survival following a switch to Faslodex (fulvestrant) plus Ibrance, according to results from the phase III PADA-1 clinical trial.
