African Americans and Hispanic people with multiple myeloma start treatment with a novel therapy significantly later than white patients, according to a study published Oct. 17 in Blood Advances.
The study found that on average it took about three months for white patients to start novel therapy after diagnosis, while it took about five months for African Americans and Hispanic patients to start novel therapy after diagnosis.
The time between diagnosis and treatment is crucial to multiple myeloma outcomes. If treatment is delayed, multiple myeloma patients can suffer organ damage, kidney dysfunction, anemia, skeletal fractures, infections and other serious conditions. Best practice is to start patients on immunomodulatory drugs such as lenalidomide and/or proteasome inhibitors such as bortezomib and carfilzomib. The use of these therapies has more than doubled survival of multiple myeloma patients within the past decade.
“We noted that minorities are not getting introduced to treatment early enough to derive adequate clinical gains,” lead author Sikander Ailawadhi, of Mayo Clinic Florida, said in a statement. “Since our analysis is based on Medicare patient data, these disparities cannot be attributed to differences in insurance coverage. Patients are not receiving treatment equally even in this ostensibly equal-access setting.”
Researchers reviewed data from the SEER–Medicare database from 2007-2013. The study included 3,504 white patients, 858 African Americans and 468 Hispanic patients. Their analysis found that the average length of time between multiple myeloma diagnosis and start of treatment for white patients was 2.7 months, compared to 4.6 months for Hispanics and 5.2 months for African Americans. Rates of autologous stem cell transplant within one year of diagnosis, considered the standard of care for eligible patients, rose among whites and African Americans but not for Hispanics.
This study found that median overall survival was similar across all groups, but comparison to previous studies suggests the survival rate for African Americans in particular has not increased as much as it could have with equal and timely access to treatment. The authors suggest the delay in treatment initiation may have inhibited African Americans’ normally better survival outcome, but this would have to be confirmed in another study.
One encouraging observation in the study was the increasing trend of beginning these therapies within the first six months of multiple myeloma diagnosis for all three race/ethnicity cohorts over the duration of the study. However, this increase was more pronounced among white and Hispanic patients compared with African Americans.
The study also found that medical costs were highest among Hispanic patients. The total monthly medical costs for whites averaged $10,143, versus $11,546 for African Americans and $12,657 for Hispanics. Researchers suggest the higher cost could be due in part to higher hospitalization costs, possibly incurred as a result of complications from delayed treatment.
