Combination therapy overcomes drug resistance in KRAS-G12C mutant cancers, study finds

Investigational therapy shrinks drug-resistant NSCLC by activating NK cells, study finds

An investigational therapy significantly shrank lung cancer tumors that are notoriously resistant to treatment by encouraging an attack from natural killer cells in an animal model, a study led by UT Southwestern Medical Center researchers shows. The findings, published in the Journal for ImmunoTherapy of Cancer, could lead to new types of immunotherapy that rely on this novel strategy.

February 21, 2025

Vol.51 No.07

Clinical Roundup

Researchers develop system which helps overcome CAR T-cell resistance in preclinical models

Researchers from City of Hope, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, the University of Pennsylvania, and NIH have developed a way to add features to T cells to help them overcome mechanisms of chimeric antigen receptor T-cell therapy resistance. The new system is outlined in a paper published in Nature Biomedical Engineering.

January 10, 2025

Vol.51 No.01

Clinical Roundup

UTSW scientists link hematopoietic cell transplant deaths to beta-blocker use

Patients can die if they take certain previously prescribed beta-blockers during a hematopoietic cell transplant due to suppressed signals from nerves that promote bone marrow regeneration, according to scientists at the Children’s Medical Center Research Institute at UT Southwestern, published in Cancer Discovery, builds upon previous CRI research by analyzing retrospective patient data to correlate beta-blocker use with significantly worse patient outcomes.

January 10, 2025

Vol.51 No.01

Clinical Roundup

UTSW scientists identify cancer-suppressing genetic mutation

UT Southwestern Medical Center researchers identified a genetic mutation that slows the growth of melanoma and potentially other cancers by harnessing the power of the immune system.

January 10, 2025

Vol.51 No.01

In Brief

UT Southwestern brings radiation oncology to $177M campus in Fort Worth Medical District

To meet the growing demands for cancer treatment in Tarrant County and surrounding areas, UT Southwestern Medical Center is expanding its cancer services in the Fort Worth Medical District with construction of a two-story radiation oncology campus that will house the city’s first MRI-guided precision radiation treatment.

December 06, 2024

Vol.50 No.45

Clinical Roundup

Kidney cancers rely on mitochondrial metabolism to metastasize, UTSW study shows

Research from Children’s Medical Center Research Institute at UT Southwestern shows that metastatic kidney cancers rely heavily on mitochondrial metabolism. These findings are contrary to how tumors operate while still in the kidney.

September 06, 2024

Vol.50 No.33

Combination therapy overcomes drug resistance in KRAS-G12C mutant cancers, study finds

YOU MAY BE INTERESTED IN

Investigational therapy shrinks drug-resistant NSCLC by activating NK cells, study finds

Researchers develop system which helps overcome CAR T-cell resistance in preclinical models

UTSW scientists link hematopoietic cell transplant deaths to beta-blocker use

UTSW scientists identify cancer-suppressing genetic mutation

UT Southwestern brings radiation oncology to $177M campus in Fort Worth Medical District

Kidney cancers rely on mitochondrial metabolism to metastasize, UTSW study shows

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