Mechanisms that clear mutations drive field cancerization in mammary tissue

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A defensive mechanism responsible for normal remodeling of breast tissue during the menstrual cycle is a potential driver of breast cancer development, according to research by the Cancer Grand Challenges research team PRECISION. 

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Researchers at Indiana University School of Medicine, Mayo Clinic, Washington University in St. Louis, the University of Pennsylvania, Columbia University, and Intel received a five-year, $3.7 million NCI grant for a multi-site study developing a privacy-preserving artificial intelligence approach—called federated learning—which aims to improve breast cancer risk prediction and reduce health inequities in cancer prevention care. 

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