Morphotek Inc., a subsidiary of Eisai Inc., entered into an agreement with the Targeted Alpha Therapy Group at the University of Gothenburg in Sweden to collaborate on the research and development of farletuzumab as an alpha therapy vector being studied for radioimmunotherapy in ovarian cancer.
Farletuzumab is an investigational humanized monoclonal antibody that binds to folate receptor alpha, a protein which is highly expressed in ovarian carcinoma but largely absent from normal tissue.
In radioimmunotherapy, mAbs are attached to radioisotopes that may potentially deliver highly cytotoxic radiation in a targeted and more direct way to relevant cancer cells. The use of alpha emitters, in contrast to beta emitters, may potentially allow for the killing of only targeted cells binding with the vector due to the short alpha particle track. This collaboration will initially investigate the use of farletuzumab as an alpha therapy vector in preclinical laboratory studies, followed by the overall objective, which is to investigate in clinical trials the safety and efficacy of alpha-radiolabeled farletuzumab in women who enter remission upon completion of first-line treatment.
Farletuzumab is currently being tested in a clinical study in first-relapsed, platinum-sensitive ovarian cancer patients with low CA125 levels. The double-blind, randomized-controlled study is designed to prospectively evaluate the clinical effects observed in the previously conducted phase III trial in the pre-specified subset of patients treated with farletuzumab exhibiting low CA125 levels.
The TAT Group’s research activities will be coordinated by various departments at the Sahlgrenska Academy, University of Gothenburg, under the direction of Associate Professor Per Albertsson, an oncologist at Sahlgrenska University Hospital.
