Insights into T-cell exhaustion could improve cancer immunotherapies, Penn study finds

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Researchers at Penn Medicine have illuminated key molecular details of the T-cell exhaustion process, identifying a specific strategy for making chimeric antigen receptor (CAR) T cell-therapy more effective against solid tumors. 

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Scientists at the Wistar Institute have identified a combination treatment that overcomes two of the biggest barriers to immunotherapy in glioblastoma. The researchers showed that reprogramming myeloid cells, a type of immune cell that glioblastoma tumors co-opt to protect themselves, while simultaneously boosting cancer-fighting T cells shrank the tumors and prevented them from coming back.
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