Exercising owner’s prerogative, City of Hope retires the Cancer Treatment Centers of America brand

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Cancer Treatment Centers of America will “fully transition” to City of Hope’s brand, giving the southern California-based cancer care health system a national footprint.

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Matthew Bin Han Ong
Matthew Bin Han Ong
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When I first proposed targeting PCNA (proliferating cell nuclear antigen) as a therapeutic approach, the response I got was: “No one will ever make a drug against PCNA. It’s undruggable.” The protein lacks enzymatic activity, has a disordered region, and binds to over 200 other proteins within the cell. From a traditional drug development perspective, these characteristics made PCNA an impossible target.
Matthew Bin Han Ong
Matthew Bin Han Ong

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