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Clinical Roundup

NCCN publishes new recommendations for treating children with brain tumors

National Comprehensive Cancer Network published new NCCN Clinical Practice Guidelines in Oncology for pediatric central nervous system cancers. 
July 15, 2022
Vol.48 No.28
Neuroblastoma researcher Robert C. Seeger dies at 82
FreeObituary

Neuroblastoma researcher Robert C. Seeger dies at 82

Robert “Bob” Seeger, a leader in research for the fight against childhood cancer, died peacefully in Bend, OR, on June 4, at age 82. 
June 17, 2022
Vol.48 No.24
By Katherine K. Matthay, Judith G. Villablanca, C. Patrick Reynolds and John M. Maris
Clinical Roundup

Five-year Kymriah data show durable remission, long-term survival in advanced B-cell ALL

Results from the ELIANA pivotal clinical trial showed the long-term benefit of Kymriah (tisagenlecleucel) in children and young adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia, with a maximum survival follow-up of 5.9 years. 
June 17, 2022
Vol.48 No.24
Clinical Roundup

FIREFLY-1 trial of DAY101 in relapsed pLGG shows positive initial data

The ongoing, open-label, single-arm, pivotal phase II FIREFLY-1 clinical trial, evaluating DAY101 (tovorafenib) as once-weekly monotherapy in patients aged 6 months to 25 years with relapsed or progressive pediatric low-grade glioma, yielded positive initial data from the first 22 patients enrolled. 
June 17, 2022
Vol.48 No.24
Lucius Sinks, a giant in pediatric cancer, dies at 91
FreeObituary

Lucius Sinks, a giant in pediatric cancer, dies at 91
“We were able to come together at Roswell Park and help the kids.”

With the aid of a cane, Dr. Lucius Sinks moved briskly through the dining room at the Boar’s Head Inn in Charlottesville, VA. At the time, he was well into his ’80s. But he remained a formidable presence, with thick white hair, dark eyes, and a wry smile.
June 10, 2022
Vol.48 No.23
By Tim Wendel
Lucius Sinks was the type of physician all of us would like to have
FreeObituary

Lucius Sinks was the type of physician all of us would like to have

Last week pediatric oncology lost another pioneer in the field, Lucius Sinks. He was 91. 
June 10, 2022
Vol.48 No.23
By Jerome Yates
FreeIn Brief

WHO and St. Jude form $200M collaboration to increase global access to childhood cancer medicines

The World Health Organization and St. Jude Children’s Research Hospital Dec. 13 announced plans to establish the Global Platform for Access to Childhood Cancer Medicines to provide an uninterrupted supply of quality-assured childhood cancer medicines to low- and middle-income countries. 
December 13, 2021
Vol.47 No.46
Drugs & Targets

FDA approves Rituxan plus chemo for pediatric cancer indications

FDA has approved Rituxan (rituximab) in combination with chemotherapy for pediatric patients (≥6 months to <18 years) with previously untreated, advanced stage, CD20-positive diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), Burkitt-like lymphoma (BLL), or mature B-cell acute leukemia (B-AL). 
December 10, 2021
Vol.47 No.45
In Brief

Tara Henderson to lead pediatric cancer, blood disease programs at UChicago

Tara O. Henderson was named the service line chief of pediatric cancer and blood diseases at the Chicagoland Children’s Health Alliance, a collaboration between University of Chicago Medicine Comer Children’s Hospital, Advocate Children’s Hospital, and Pediatrics at NorthShore University HealthSystem. 
December 03, 2021
Vol.47 No.44

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