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The Cancer Letter
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Clinical Roundup

Oncolytic virus treatment produces promising results for TNBC in phase II study

In an article published in Nature Medicine, Moffitt Cancer Center researchers, led by Hatem Soliman, share results from a phase II clinical study of the oncolytic virus talimogene laherparepvec combined with standard chemotherapy in patients with early stage triple-negative breast cancer. 
February 10, 2023
Vol.49 No.06
Clinical Roundup

Uncertainty about breast cancer risk and screening choices increase with breast density awareness

Awareness of breast density appears to increase one’s perceived breast cancer risk for a short time after undergoing mammography in Northern Manhattan according to a study at Columbia University Mailman School of Public Health. 
February 10, 2023
Vol.49 No.06
Clinical Roundup

Study finds large gap in breast cancer treatment recommendations for patients aged 70 vs 69

Age-based heuristics can lead to large differences in breast cancer treatment based on small differences in chronologic age, according to a new analysis of more than 500,000 patient records.
February 03, 2023
Vol.49 No.05
Clinical Roundup

SWOG S1416 study results show PARP inhibitor benefit in “BRCA-like” breast cancer

Results from the SWOG S1416 clinical trial showed that adding veliparib to chemotherapy can significantly extend progression-free survival times in patients with TNBC that has a “BRCA-like” phenotype.
February 03, 2023
Vol.49 No.05
Drugs & Targets

Orserdu & companion diagnostic for ER+, HER2-, ESR1-mutated advanced breast cancer receive FDA approval

FDA approved Orserdu (elacestrant) for postmenopausal women or adult men with ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy.
February 03, 2023
Vol.49 No.05
Clinical Roundup

Medical College of Wisconsin scientists find marker that may predict immunotherapy response in ER+ breast cancer

A multi-institutional team led by scientists from the Medical College of Wisconsin Cancer Center has discovered PD-L2 as a therapy-relevant marker to identify patients with estrogen receptor-positive breast cancer who may benefit from new immunotherapies.
January 27, 2023
Vol.49 No.04
Kay Dickersin: How NBCC started Project LEAD to teach science to breast cancer patients
Cancer History ProjectConversation with The Cancer LetterFree

Kay Dickersin: How NBCC started Project LEAD to teach science to breast cancer patients

When Kay Dickersin was diagnosed with breast cancer in 1986, the support group available to her in Baltimore focused largely on how to get the makeup and wig to look right.
January 13, 2023
Vol.49 No.02
By Alexandria Carolan
A new photo archive highlights NBCC’s impact in the 1990s
FreeIn the Archives

A new photo archive highlights NBCC’s impact in the 1990s

In an interview with the Cancer History Project, Kay Dickersin, one of the early leaders of the grassroots breast cancer patient advocacy movement, recounted the beginnings of the National Breast Cancer Coalition. 
January 13, 2023
Vol.49 No.02
Clinical Roundup

Oral paclitaxel combination shows positive results for TNBC subgroup in phase II study

A regimen including oral paclitaxel plus Athenex (encequidar) in combination with a PD-1 inhibitor and carboplatin showed positive results in triple-negative, high-risk, early-stage breast cancer. The oral paclitaxel, relative to intravenous paclitaxel, was associated with less neuropathy and was not associated with an increase in febrile neutropenia. 
January 06, 2023
Vol.49 No.01
Clinical Roundup

IU research points to a biomarker for cardiotoxicity in breast cancer–and a role for dexamethasone

An Indiana University School of Medicine study produced a potential biomarker for chemotherapy-induced cardiotoxicity in breast cancer patients. The researchers also identified a drug that may work to minimize cardiotoxicity.
January 06, 2023
Vol.49 No.01

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