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The Cancer Letter
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Clinical Roundup

Cyclophosphamide may expand transplant donor pool for patients with blood cancers

A new treatment approach using an older drug may enable more patients with high-risk blood cancers to receive transplanted stem cells from unrelated, partially matched donors, according to a study conducted by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and colleagues.
May 24, 2024
Vol.50 No.21
Clinical Roundup

Older adults with aggressive blood cancer are responsive to treatment and show prolonged survival

Standard of care treatment for acute myeloid leukemia is safe and effective for adults over 80, according to a study published in Blood Neoplasia. For roughly a quarter of patients, this treatment can durably prolong survival.
May 17, 2024
Vol.50 No.20
ODAC gives thumbs-up to imetelstat for MDS, upholding the value of transfusion independence
Regulatory News

ODAC gives thumbs-up to imetelstat for MDS, upholding the value of transfusion independence

The FDA Oncologic Drugs Advisory Committee voted 12:2 to recommend approval of the drug imetelstat for a myelodysplastic syndrome indication.
March 15, 2024
Vol.50 No.11
By Jacquelyn Cobb and Paul Goldberg
In Brief

University of Cincinnati opens blood cancer healing center

The University of Cincinnati Cancer Center has opened the Blood Cancer Healing Center, a facility that aims to advance research, treatment, and wellness for blood cancer patients. 
February 16, 2024
Vol.50 No.07
After revolutionizing treatment of blood cancers, imatinib stands poised to eradicate malaria

After revolutionizing treatment of blood cancers, imatinib stands poised to eradicate malaria

Imatinib—the pathbreaking cancer drug that gave Philadelphia chromosome-positive chronic myeloid leukemia patients near-normal life expectancies—now stands poised to save even more lives. 
November 03, 2023
Vol.49 No.41
By Jacquelyn Cobb
Yale’s Richard Edelson on what got him started in research for cutaneous T-cell lymphoma
FreeIn the Archives

Yale’s Richard Edelson on what got him started in research for cutaneous T-cell lymphoma

Richard Edelson began his career at NCI, where he was training to become a cancer immunologist. 
October 27, 2023
Vol.49 No.40
Drugs & Targets

FDA approves Ojjaara as first and only treatment for myelofibrosis with anemia

FDA has approved Ojjaara (momelotinib) for the treatment of intermediate or high-risk myelofibrosis, including primary myelofibrosis or secondary myelofibrosis (post-polycythaemia vera and post-essential thrombocythemia), in adults with anemia. 
September 22, 2023
Vol.49 No.35
In Brief

Jonathan Licht and Keith McCrae to lead new Blood specialty journals

Jonathan D. LichtKeith McCraeJonathan Licht and Keith McCrae were selected by The American Society of Hematology to serve as the inaugural editors-in-chief of the newest additions to the Blood Journals portfolio: Blood Neoplasia and Blood Vessels, Thrombosis & Hemostasis, or Blood VTH. 
September 15, 2023
Vol.49 No.34
John Laszlo’s dual role: (1) Working to cure childhood leukemia, and (2) Writing the authoritative book on it
Cancer History ProjectConversation with The Cancer LetterFree

John Laszlo’s dual role: (1) Working to cure childhood leukemia, and (2) Writing the authoritative book on it
His father, Daniel Laszlo, did early work on folate antagonists

When John Laszlo joined the Acute Leukemia Service at NCI in 1956, the field of oncology was nascent—and the cure for childhood leukemia seemed beyond reach. 
August 11, 2023
Vol.49 No.32
By Alexandria Carolan and Paul Goldberg
Karnofsky winner Hagop Kantarjian: We changed the course of leukemias from mostly incurable to mostly curable
Cancer History ProjectConversation with The Cancer Letter

Karnofsky winner Hagop Kantarjian: We changed the course of leukemias from mostly incurable to mostly curable

Leukemia was mostly a fatal disease when Hagop Kantarjian, a medical student at the American University of Lebanon in Beirut, first came to MD Anderson in  1978. 
May 26, 2023
Vol.49 No.21
By Jacquelyn Cobb

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