Candel Therapeutics Inc., a clinical-stage biopharmaceutical company developing viral immunotherapies, formed a collaboration with the University of Pennsylvania to study the impact of novel viral immunotherapies based on Candel’s proprietary enLIGHTEN Discovery Platform to strengthen the effects of Penn’s CAR-T cell therapies in solid tumor models.
Data from the phase Ib/II OrigAMI-4 study found that first-line treatment with investigational subcutaneous amivantamab and hyaluronidase-lpuj in combination with a PD-1 inhibitor delivered clinically meaningful and durable antitumor activity in patients with head and neck squamous cell carcinoma that is recurrent or metastatic, PD-L1-positive, and HPV-unrelated.
