Priority Review granted to lenvatinib in thyroid cancer

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FDA granted priority review status to lenvatinib mesylate as a treatment for progressive radioactive iodine-refractory differentiated thyroid cancer.

Developed by Eisai Inc., lenvatinib is an oral multiple receptor tyrosine kinase inhibitor that blocks the kinase activities of vascular endothelial growth factor receptors, in addition to other proangiogenic and oncogenic pathway-related tyrosine kinases thought to be involved in tumor proliferation. These include fibroblast growth factor receptors, the platelet-derived growth factor receptor PDGFR, KIT and RET, which are thought to be involved in tumor proliferation.

Lenvatinib was granted orphan drug designation in various types of thyroid cancer in the U.S., Japan, and Europe. It is currently under investigation in thyroid, hepatocellular, endometrial, non-small cell lung cancer, and other solid tumor types.

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I write a weekly blog for Georgetown University’s Lombardi Comprehensive Cancer Center community. Here I share an updated version of a blog post I wrote in September 2024, now supplemented by some poems I have written over the years that inspired paintings by my wife Harriet Weiner, who is a much better artist than I am a poet or writer. 

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