A phase IIb clinical trial for Galera Therapeutics’ GC4419 met its primary endpoint, demonstrating a significant (p=0.024), clinically meaningful and dose-dependent reduction in the duration of severe oral mucositis in patients with head and neck cancer receiving chemoradiation.
Researchers from the University of Chicago Medicine Comprehensive Cancer Center demonstrated the potential of a novel treatment approach including immunotherapy to treat advanced human papillomavirus-negative head-and-neck squamous cell carcinoma. More than half of study participants had 50% or more of their tumors shrink after receiving the immunotherapy drug nivolumab with chemotherapy, followed by response-adaptive chemo-radiation therapy.
