Olaparib phase III SOLO-2 trial demonstrates significant PFS benefit in BRCA-mutated disease

Researchers identify “master regulator” gene that could lead to more effective ovarian cancer treatment

Researchers have identified a “master regulator” gene, ZNFX1, that may act as a biomarker to help guide treatment in future clinical trials involving patients with therapy-resistant ovarian cancer, according to a study recently published in Cancer Research.

April 04, 2025

Vol.51 No.13

Clinical Roundup

Elahere shows survival benefit in long-term analysis for ovarian cancer patients in phase III study

AbbVie announced the final analysis of the confirmatory phase III MIRASOL trial evaluating the efficacy and safety of Elahere in women with folate receptor alpha-positive platinum-resistant ovarian cancer compared to chemotherapy.

March 21, 2025

Vol.51 No.11

Clinical Roundup

Genmab’s Rina-S shows promise in treating advanced ovarian cancer

Genmab A/S announced on March 17 updated data from cohort B1 of the phase I/II RAINFOL-01 study of rinatabart sesutecan, an investigational folate receptor-alpha-targeted, TOPO1 antibody-drug conjugate that showed Rina-S 120 mg/m2 every three weeks resulted in a confirmed objective response rate of 55.6% (95% CI: 30.8-78.5) in heavily pre-treated ovarian cancer patients regardless of FRα expression levels.

March 21, 2025

Vol.51 No.11

Clinical Roundup

Pitt study offers insights into ovarian cancer’s origins

Researchers at the University of Pittsburgh have identified a trigger of high-grade serous ovarian cancer: a subset of progenitor cells that reside in fallopian tube supportive tissue, or stroma.

March 14, 2025

Vol.51 No.10

Clinical Roundup

Mayo Clinic researchers identify new immunotherapy target for ovarian cancer

Mayo Clinic researchers have discovered a new immunotherapy target, a cryptic antigen, may be key in helping the immune system fight tumors in ovarian cancer. The study, published in Science Advances, could improve treatment approaches for this type of cancer.

February 21, 2025

Vol.51 No.07

Clinical Roundup

Fertility treatment increases risk for ovarian cancer, review finds

Fertility treatment increases the odds of ovarian cancer but not breast, endometrial, or cervical cancer, according to the results of an umbrella review published in Fertility and Sterility.

January 17, 2025

Vol.51 No.02

Olaparib phase III SOLO-2 trial demonstrates significant PFS benefit in BRCA-mutated disease

YOU MAY BE INTERESTED IN

Researchers identify “master regulator” gene that could lead to more effective ovarian cancer treatment

Elahere shows survival benefit in long-term analysis for ovarian cancer patients in phase III study

Genmab’s Rina-S shows promise in treating advanced ovarian cancer

Pitt study offers insights into ovarian cancer’s origins

Mayo Clinic researchers identify new immunotherapy target for ovarian cancer

Fertility treatment increases risk for ovarian cancer, review finds

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