The Cancer Letter

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Clinical

Phase III MARIANNE Study Fails To Improve PFS with Kadcyla in HER2-Positive Breast Cancer

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Top-line results of the phase III MARIANNE study evaluated three HER2-targeted regimens—Kadcyla (ado-trastuzumab emtansine) plus Perjeta (pertuzumab), Kadcyla alone, and Herceptin (trastuzumab) plus taxane chemotherapy—in people with previously untreated advanced HER2-positive breast cancer.

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