Johnson & Johnson announced results from the open-label phase II SKIPPirr study, which evaluated additional prophylactic strategies to reduce the incidence of infusion-related reactions with intravenous Rybrevant (amivantamab-vmjw) in patients with advanced non-small cell lung cancer with epidermal growth factor receptor exon 19 deletions or L858R substitution mutations.
The SWOG S2302 Pragmatica-Lung trial, which broke new ground with its streamlined pragmatic design, unusually broad eligibility criteria, and reduced data collection, has quickly answered its primary question, finding that the investigational combination it tested did not significantly extend overall survival compared to standard of care treatments.
