NEOSTAR phase II platform trial demonstrates neoadjuvant immunotherapy can enhance response in operable NSCLC

Vanderbilt receives $1M grant to fund immunotherapy research in CRC

The Robert J. Kleberg Jr. and Helen C. Kleberg Foundation awarded a $1 million grant to support research at Vanderbilt aimed at dramatically expanding the efficacy of immunotherapy for colorectal cancer.

October 04, 2024

Vol.50 No.37

Drugs & Targets

FDA approves neoadjuvant/adjuvant Opdivo for resectable NSCLC

FDA approved Opdivo (nivolumab) with platinum-doublet chemotherapy as neoadjuvant treatment, followed by single-agent Opdivo after surgery as adjuvant treatment, for adults with resectable (tumors ≥ 4 cm and/or node positive) non-small cell lung cancer and no known epidermal growth factor receptor mutations or anaplastic lymphoma kinase rearrangements.

October 04, 2024

Vol.50 No.37

Regulatory News

ODAC votes overwhelmingly in support of PD-L1 expression as predictive biomarker for efficacy of checkpoint inhibitors
Vote applies across drugs and indications

The FDA Oncologic Drugs Advisory Committee on Sept. 26 voted that PD-L1 inhibitors should not be indicated for patients with PD-L1-negative gastric/gastroesophageal junction adenocarcinoma and esophageal squamous cell carcinoma.

Rybrevant + chemo shows improved OS data in NSCLC

Updated results from the phase III MARIPOSA-2 study showed Rybrevant (amivantamab-vmjw) combined with chemotherapy led to consistent benefit across post-progression outcomes in adult patients with previously treated NSCLC with epidermal growth factor receptor exon 19 deletions or L858R substitution mutations.

September 20, 2024

Vol.50 No.35

Drugs & Targets

FDA approves Rybrevant + pemetrexed + chemo in NSCLC with EGFR exon 19 deletions or L858R mutations

FDA approved Rybrevant (amivantamab-vmjw) with carboplatin and pemetrexed for adult patients with locally advanced or metastatic non-small cell lung cancer with epidermal growth factor receptor exon 19 deletions or exon 21 L858R substitution mutations whose disease has progressed on or after treatment with an EGFR tyrosine kinase inhibitor.

September 20, 2024

Vol.50 No.35

Clinical Roundup

Friends publishes evaluation of RWE in NSCLC

Findings by Friends of Cancer Research were published recently in JCO Clinical Cancer Informatics in a paper titled “Evaluation of real-world tumor response derived from electronic health record data sources: A feasibility analysis in mNSCLC patients treated with chemotherapy.”

September 13, 2024

Vol.50 No.34

NEOSTAR phase II platform trial demonstrates neoadjuvant immunotherapy can enhance response in operable NSCLC

YOU MAY BE INTERESTED IN

Vanderbilt receives $1M grant to fund immunotherapy research in CRC

FDA approves neoadjuvant/adjuvant Opdivo for resectable NSCLC

ODAC votes overwhelmingly in support of PD-L1 expression as predictive biomarker for efficacy of checkpoint inhibitors
Vote applies across drugs and indications

Rybrevant + chemo shows improved OS data in NSCLC

FDA approves Rybrevant + pemetrexed + chemo in NSCLC with EGFR exon 19 deletions or L858R mutations

Friends publishes evaluation of RWE in NSCLC

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NEOSTAR phase II platform trial demonstrates neoadjuvant immunotherapy can enhance response in operable NSCLC

YOU MAY BE INTERESTED IN

Vanderbilt receives $1M grant to fund immunotherapy research in CRC

FDA approves neoadjuvant/adjuvant Opdivo for resectable NSCLC

ODAC votes overwhelmingly in support of PD-L1 expression as predictive biomarker for efficacy of checkpoint inhibitorsVote applies across drugs and indications

Rybrevant + chemo shows improved OS data in NSCLC

FDA approves Rybrevant + pemetrexed + chemo in NSCLC with EGFR exon 19 deletions or L858R mutations

Friends publishes evaluation of RWE in NSCLC

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ODAC votes overwhelmingly in support of PD-L1 expression as predictive biomarker for efficacy of checkpoint inhibitors
Vote applies across drugs and indications