Neoadjuvant nivolumab shows long-term benefit in NSCLC

Immunotherapy + radiation show promise for bladder preservation in localized MIBC, phase II study shows

Patients with localized muscle-invasive bladder cancer who received radiation plus the immune checkpoint inhibitors durvalumab (Imfinzi) and tremelimumab (Imjudo) had durable responses that allowed for bladder preservation, according to results from the IMMUNOPRESERVE clinical study published in Clinical Cancer Research, a journal of the AACR.

February 21, 2025

Vol.51 No.07

Clinical Roundup

Investigational therapy shrinks drug-resistant NSCLC by activating NK cells, study finds

An investigational therapy significantly shrank lung cancer tumors that are notoriously resistant to treatment by encouraging an attack from natural killer cells in an animal model, a study led by UT Southwestern Medical Center researchers shows. The findings, published in the Journal for ImmunoTherapy of Cancer, could lead to new types of immunotherapy that rely on this novel strategy.

February 21, 2025

Vol.51 No.07

Clinical Roundup

CAR T therapy shows durable responses in large B-cell lymphoma

Allogene Therapeutics Inc. announced the publication of data from its phase I ALPHA and ALPHA2 clinical studies of cemacabtagene ansegedleucel (cema-cel; formerly ALLO-501/A) in relapsed/refractory large B-cell lymphoma as a rapid communication in the Journal of Clinical Oncology.

February 21, 2025

Vol.51 No.07

Clinical Roundup

Scientists identify dysfunctional B cells as a new cancer immunotherapy target

University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center scientists have discovered a novel subset of cancer-fighting immune cells that reside outside of their normal neighborhood—known as the tertiary lymphoid structure—where they become dysfunctional when in close contact with tumors.

February 21, 2025

Vol.51 No.07

Clinical Roundup

Mayo Clinic researchers identify new immunotherapy target for ovarian cancer

Mayo Clinic researchers have discovered a new immunotherapy target, a cryptic antigen, may be key in helping the immune system fight tumors in ovarian cancer. The study, published in Science Advances, could improve treatment approaches for this type of cancer.

February 21, 2025

Vol.51 No.07

Drugs & Targets

FDA grants priority review to Boehringer’s BI 1810631 for the treatment of HER2-mutant advanced NSCLC

FDA granted priority review to Boehringer Ingelheim’s new drug application for BI 1810631 (zongertinib) for the treatment of adult patients with unresectable or metastatic non-small cell lung cancer whose tumors have HER2 mutations and who have received prior systemic therapy.

February 21, 2025

Vol.51 No.07

Neoadjuvant nivolumab shows long-term benefit in NSCLC

YOU MAY BE INTERESTED IN

Immunotherapy + radiation show promise for bladder preservation in localized MIBC, phase II study shows

Investigational therapy shrinks drug-resistant NSCLC by activating NK cells, study finds

CAR T therapy shows durable responses in large B-cell lymphoma

Scientists identify dysfunctional B cells as a new cancer immunotherapy target

Mayo Clinic researchers identify new immunotherapy target for ovarian cancer

FDA grants priority review to Boehringer’s BI 1810631 for the treatment of HER2-mutant advanced NSCLC

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