N-803 immunotherapy may improve responses in BCG-unresponsive bladder cancer, advanced metastatic pancreatic cancer

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Positive data from a pivotal phase II/III trial for BCG-unresponsive non-muscle invasive bladder cancer carcinoma in situ (QUILT 3032) and phase II trial in advanced pancreatic cancer (QUILT 88) were announced at the 2022 ASCO annual meeting.

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Keytruda (pembrolizumab) plus Padcev (enfortumab vedotin-ejfv) reduced the risk of event-free survival events by 60% and reduced the risk of death by 50% when given before and after surgery (radical cystectomy) versus surgery alone, the current standard of care, in patients with muscle-invasive bladder cancer who are not eligible for or declined cisplatin-based chemotherapy, according to phase III KEYNOTE-905/EV-303 trial data. 
Positive results from the POTOMAC phase III trial showed adding one year of treatment with Imfinzi (durvalumab) to BCG induction and maintenance therapy demonstrated a statistically significant and clinically meaningful improvement in disease-free survival for patients with BCG-naïve, high-risk non-muscle-invasive bladder cancer compared to BCG treatment alone.

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