The NCI-60, a panel of 60 cancer cell lines that have become the Rosetta Stone for the development of anticancer drugs, may be entering its twilight years as NCI develops new, and more expansive, patient-derived xenografts, or PDX models.
The National Cancer Institute Cancer Therapy Evaluation Program approved the following clinical research studies last month. For further information, contact the principal investigator listed.
A clinical utility study claimed use of the Afirma Gene Expression Classifier, developed by Veracyte Inc., can significantly reduce unnecessary surgeries in thyroid cancer diagnoses. The study was published in Cancer Cytopathology.
Results of the LUX-Lung 7 trial met two of its co-primary endpoints, in progression-free survival and time to treatment failure, with EGFR-directed therapy Gilotrif (afatinib) compared to Iressa (gefitinib) in the first-line treatment of patients with advanced non-small cell lung cancer.
Two analyses presented during the American Society of Clinical Oncology's 2016 Gastrointestinal Cancers Symposium evaluated the results of second-line treatment following treatment with a combination of Abraxane (paclitaxel protein-bound particles for injectable suspension; albumin-bound) and gemcitabine in first-line metastatic pancreatic cancer patients.
OBI Pharma Inc., announced topline results from a phase II/III study of OBI-822/821 (formerly OPT822/OPT821), which evaluated the clinical benefit and immunogenicity in patients with metastatic breast cancer. The study did not meet the primary efficacy endpoint of progression-free survival.
FDA approved Gazyva (obinutuzumab) plus bendamustine chemotherapy followed by Gazyva alone as a new treatment for people with follicular lymphoma who did not respond to a Rituxan (rituximab)-containing regimen, or whose follicular lymphoma returned after such treatment.
Full results from a phase III study showed improved median overall survival in unresectable locally advanced liposarcomas and leiomyosarcomas in patients receiving Halaven (eribulin), compared to dacarbazine.
A phase III study of Blincyto met its primary endpoint of overall survival in patients with acute lymphoblastic leukemia following a prespecified interim analysis. The study was stopped early.
INDIANA UNIVERSITY Melvin and Bren Simon Cancer Center received a $100,000 women’s cancer research grant from the Kay Yow Cancer Fund. Since 2009, the Kay Yow Cancer Fund has supported a women’s cancer research grant at an institution based in the host city of the annual NCAA Women’s Final Four. This year’s grant was awarded... […]
