Relying largely on maturing data from the European trials of screening for prostate cancer, the U.S. Preventive Services Task Force has given a better grade—a “C”—to screening for prostate cancer.
FDA approved rucaparib (Rubraca), a poly ADP-ribose polymerase inhibitor, for the maintenance treatment of recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy.
FDA has finalized two guidances to drive the efficient development of a novel technology that scans a person's DNA to diagnose genetic diseases, which are usually hereditary, and guide medical treatments. The guidances provide recommendations for designing, developing, and validating tests that use the technology, called next generation sequencing.
Karyopharm Therapeutics Inc. received the FDA Fast Track designation for an oral Selective Inhibitor of Nuclear Export compound selinexor for the treatment of patients with multiple myeloma who have received at least three prior lines of therapy.
Nanobiotix and MD Anderson Cancer Center said they will collaborate on preclinical research involving NBTXR3, Nanobiotix's lead product.
In a new study, researchers identified genetic subtypes of diffuse large B-cell lymphoma that could help explain why some patients with the disease respond to treatment and others don't.
The American Society for Radiation Oncology issued an update to its clinical guideline for the use of palliative-intent radiation therapy for patients with incurable non-small cell lung cancer.
Merck said the pivotal phase III KEYNOTE-042 trial evaluating Keytruda, Merck's anti-PD-1 therapy, as monotherapy for the first-line treatment of locally advanced or metastatic non-small cell lung cancer (including nonsquamous or squamous histologies) met its primary endpoint of overall survival.
Incyte Corp. and Merck said an external Data Monitoring Committee review of the pivotal phase III ECHO-301/KEYNOTE-252 study results evaluating Incyte's epacadostat in combination with Merck's Keytruda in patients with unresectable or metastatic melanoma determined that the study did not meet the primary endpoint of improving progression-free survival in the overall population compared to Keytruda monotherapy.
Researchers at Roswell Park Comprehensive Cancer Center and the Ohio State University has identified a link between rare variants in a number of novel genes and survival after transplantation of blood and marrow from an unrelated donor, opening avenues for improving individual risk prediction and prognosis for patients undergoing BMT.
