Data from the National Coalition for Cancer Survivorship's 2020 State of Cancer Survivorship Survey show that cancer survivors are likely to rely on their doctor to tell them what treatment option is best.
The phase III VIALE-A clinical trial evaluating newly-diagnosed AML patients who had not yet been treated and were unable to tolerate traditional intensive chemotherapy, found that venetoclax in combination with azacitidine extended overall survival compared to azacitidine plus placebo.
Opdivo (nivolumab) plus Yervoy (ipilimumab) demonstrated a significant improvement in overall survival in patients with previously untreated, unresectable malignant pleural mesothelioma in the phase III CheckMate -743 clinical trial.
CheckMate -649, a pivotal phase III trial evaluating Opdivo plus chemotherapy compared to chemotherapy alone as a first-line treatment for metastatic gastric cancer, gastroesophageal junction cancer or esophageal adenocarcinoma, met both primary endpoints of overall survival at a pre-specified interim analysis and progression-free survival at final analysis in patients whose tumors express PD-L1 with a combined positive score (CPS) ≥ 5.
The phase III CheckMate -577 trial evaluating Opdivo (nivolumab) as an adjuvant therapy for patients with resected esophageal or gastroesophageal junction cancer met its primary endpoint of disease-free survival at a pre-specified interim analysis.
The phase III IMpassion131 study evaluating Tecentriq in combination with paclitaxel (chemotherapy), in comparison to placebo plus paclitaxel, did not meet statistical significance on its primary endpoint of progression-free survival for the initial (first-line) treatment of people with metastatic triple-negative breast cancer, in the PD-L1-positive population.
City of Hope surgical researchers are assessing whether pressurized intraperitoneal aerosolized chemotherapy can be an effective way to deliver chemotherapy to abdominal cancer patients.
Two phase I/II trials that evaluated the safety and efficacy of CD30 CAR-T cell therapy in patients with relapsed/refractory Hodgkin lymphoma showed a high rate of durable complete responses and very favorable safety profile using autologous CD30 CAR-T cell therapy.
Researchers at The Ohio State University Comprehensive Cancer Center—Arthur G. James Cancer Hospital and Richard J. Solove Research Institute conducted a retrospective study that could refine predicted survival outcomes and treatment in younger adults with acute leukemia.
Scientists have developed the most accurate computing method to date to reconstruct the patchwork of genetic faults within tumors and their history during disease development, in new research funded by Cancer Research UK and published in Nature Genetics.
