Through a genomic screening method known as CRISPR/CAS9 screening, Massey scientists—led by Anthony Faber and Jennifer Koblinski—identified a specific enzyme called UBA1 that revealed itself as an ideal therapeutic target in triple negative breast cancer. Using a novel UBA-inhibiting drug called TAK-243, they blocked the cellular function of UBA1 and effectively killed cancer cells in patient-derived breast tumors in mice.
Researchers recently completed the first human trial of proton FLASH radiotherapy at the Cincinnati Children’s/University of Cincinnati Medical Center Proton Therapy Center. FLASH RT was shown to be as safe and appeared to be as effective as conventional radiation without causing unexpected side effects in the study in a small number of people with bone cancer.
An analysis of data on the use of radiation therapy in a large clinical trial of patients with HR+, HER2- breast cancer who had one to three involved lymph nodes and a 21-gene recurrence score of 25 or less found that rates of locoregional recurrence of the disease were low regardless of whether a patient had received regional node irradiation. The results suggest that a randomized clinical trial is required to answer the question of whether these favorable-risk patients can safely skip RNI.
FDA approved Imjudo (tremelimumab) in combination with Imfinzi (durvalumab) for adult patients with unresectable hepatocellular carcinoma.
FDA granted accelerated approval to Tecvayli (teclistamab-cqyv), the first bispecific B-cell maturation antigen-directed CD3 T-cell engager, for adult patients with relapsed or refractory multiple myeloma who have received at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody.
FDA issued marketing denial orders for several e-cigarette products currently marketed by Logic Technology Development LLC.
The National Academy of Medicine announced the election of 90 regular members and 10 international members during its annual meeting. Election to the Academy is considered one of the highest honors in the fields of health and medicine and recognizes individuals who have demonstrated outstanding professional achievement and commitment to service.
Oksana Leontyeva, an expert in hematologic malignancies, was killed in a Russian rocket attack as she was rushing through central Kyiv to take care of her patients at OKHMATDYT, the biggest children’s hospital in Ukraine.
Sudhir Srivastava won the Don Listwin Award for Outstanding Contribution to Cancer Early Detection.
Don S. Dizon has been named the inaugural vice chair for diversity, equity, inclusion, and professional integrity with the SWOG Cancer Research Network.
