publication date: Aug. 4, 2015
20150804 - Aug. 4, 2015
July 2015PDF

 

Lymphoma

Phase II Trial Shows Benefit with Imbruvica In Activated B-cell-like Subtype of DLBCL

A phase II clinical trial identified patients with a specific molecular subtype of diffuse large B-cell lymphoma that are more likely to respond to Imbruvica (ibrutinib) treatment.

In the trial, patients with the activated B-cell-like subtype of DLBCL were more likely to respond to Imbruvica than patients with the germinal center B-cell-like subtype. The trial was jointly conducted by NCI and Pharmacyclics Inc., and was published in Nature Medicine.

 

Drugs and Targets

FDA Approves Odomzo in Advanced BCC, Kyprolis Combination in Multiple Myeloma

FDA approved Odomzo (sonidegib) capsules for the treatment of patients with locally advanced basal cell carcinoma that has recurred following surgery or radiation therapy, or those who are not candidates for surgery or radiation therapy. Odomzo is marketed by Novartis Pharmaceuticals Corp.

The approval was based on demonstration of a durable objective response rate in an international, multi-center, double-blind, randomized, two-arm, non-comparative trial in patients with locally advanced basal cell carcinoma not amenable to local therapy or metastatic basal cell carcinoma.

 

Prostate Cancer

Researchers: As Many as 40% of Patients Could be Receiving Overtreatment

As many as 40 percent of patients with lower-risk prostate cancers may be currently receiving overtreatment, according to researchers that examined common treatment practices.

Monitoring men with very low- and low-risk prostate cancers using watchful waiting or active surveillance, or expectant management, is a useful approach for a large number of men with localized tumors and could spare them the debilitating side effects of aggressive treatments that are too often unnecessarily used in this patient population, according to a study led by researchers at UCLA.

 

Colorectal Cancer

Vectibix Improves OS in Phase III Trial of mCRC

 

Liver Cancer

Cyramza Trial Fails OS Endpoint; Subgroup Data to Form New Study

 

Leukemia

Pracinostat/Vidaza Combination Shows Response in Phase II Trial

 

Bladder Cancer

Study: Robotic Surgery Shows Long-term Results Similar to Traditional Open Surgery

 

NCI CTEP-Approved Trials for the Month of July

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