publication date: Mar. 27, 2015
20150327 - Mar. 27, 2015
ISSUE 12 – MARCH 27, 2015PDF

“All Pull; No Push”—Varmus Describes his Reasons for Leaving In Farewell Town Hall

In a farewell town hall meeting March 24, NCI Director Harold Varmus reflected on statements he made during his first day on the job, July 12, 2010, summarizing the proceeding four-and-three-quarter years; listing goals met and lamenting work left unfinished.

After Varmus steps down March 31, he will be replaced by Deputy Director Douglas Lowy, who will become the acting director.

Varmus’s remarks ranged from his reasons for leaving NCI—“All pull; no push”—to the accomplishments of the institute during his tenure, and lessons learned from obstacles unforeseen.

He discussed his Provocative Questions initiative and sequestration; the RAS initiative and the Frederick National Lab; as well as the formation of the National Clinical Trials Network and the completion of the National Lung Screening Trial.

Guest Editorial

How the Lung-MAP Clinical Trial is Responding to Rapidly Changing Science

By Roy S. Herbst, David Gandara and Vassiliki Papadimitrakopoulou

When the Lung Master Protocol clinical trial (Lung-MAP or S1400) (1) was launched in June 2014, the goal of this first-of-its kind trial was simple: find effective treatments for seriously ill patients suffering from a specific type of lung cancer.

Lung-MAP is unique—a biomarker driven, multi-drug, multi-arm, study design, using a targeted screening approach, with state-of-the-art genomic profiling of neoplastic cells to match patients with sub-studies testing investigational new drugs and immunotherapies, based on their unique tumor profiles.

Seventeen Percent of MD Anderson Faculty Signed Petition Disagreeing with Faculty Senate Executive Committee

About 17 percent of the faculty members at MD Anderson Cancer Center signed a petition that disagreed with the institution’s Faculty Senate in its efforts to step in and improve morale at the Houston-based institution.

The Faculty Senate recently sent out a letter requesting that the UT System officials and the Board of Regents “provide guidance” to the MD Anderson administration “in establishing milestones and timelines to implement measures to improve the morale of the faculty and the general health of the Institution.”

 

Republican Budgets Propose $5 Trillion Cut, On Top of Sequestration, Through 2025

The Senate passed its 2016 budget early Friday morning in a marathon voting session—an event called “vote-a-rama” in Washington-speak—that split along party lines with a 52-46 Republican margin.

The Senate budget resolution would slash $5.1 trillion in federal spending over the next decade, mirroring the resolution passed by the House 228 to 199 March 25, which cut spending by $5.5 trillion over the next nine years.

Both budgets agree on keeping sequestration cuts in place, and on repealing the Affordable Care Act.

House Votes to Repeal Sustainable Growth Rate; Senate Delays Action

The House voted 392-37 to approve legislation that would eliminate the Sustainable Growth Rate, a method currently used by the Centers for Medicare and Medicaid Services to control spending by Medicare on physician services.

While the House voted on March 26, the Senate adjourned for spring recess without acting on the bill.

Physicians are now faced with the prospect of a 21 percent cut in Medicare reimbursement when the current SGR payment patch expires next week on March 31.

Report: 2 in 5 Cancer Patients “Seriously Concerned” About Bankruptcy

Out-of-pocket costs for health care remain a top concern for many people living with cancer, according to a report by the Cancer Support Community, an international nonprofit.

The study, “An Insight into Patient Access to Care in Cancer,” surveyed 511 cancer patients, 480 of whom live in the U.S. Nearly 90 percent of the respondents were women, and nearly two-thirds were between the ages of 45 and 64.

Pitt, Carnegie Mellon and UPMC Form Big Data Alliance

Three Pittsburgh institutions—Carnegie Mellon University, the University of Pittsburgh, and the University of Pittsburgh Medical Center—are pooling their electronic medical records to form the Pittsburgh Health Data Alliance.

The alliance is funded by UPMC and designed to support applied research and commercialization, along with basic foundational research in medicine and computer science. UPMC Enterprises, the commercialization arm of UPMC, will lead the effort.

In Brief

  • FDA’s Richard Pazdur named one of 50 World’s Greatest Leaders by Fortune magazine

  • Elizabeth Jaffee receives clinical care research award from AACR

  • Jimmie Holland receives Women of Influence award

  • Gairdner Foundation names 2015 award winners

  • Bloomberg Philanthropies to launch Data for Health system

Drugs and Targets

  • CHMP grants positive opinion to Gardasil 9 HPV vaccine

  • EMA grants orphan designation to Reolysin

  • Teikoku Pharma USA submits NDA for alcohol-free docetaxel formulation

  • Rich Pharmaceuticals plans to launch clinical trials at Khon Kaen University in Thailand

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