Multi-ethnic study uncovers unique origins of melanoma types and actionable molecular targets

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Scientists from the International Agency for Research on Cancer, Barretos Cancer Hospital (Brazil), and partners have identified multi-omics markers of exposure to ultraviolet radiation that are critically involved in immune function, have the potential to drive cancer development, and could be used to predict the survival of patients with cutaneous melanoma, which occurs mainly in fair-skinned people. 

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Roger Lo, professor of medicine, dermatology, and molecular and medical pharmacology and investigator at the UCLA Health Jonsson Comprehensive Cancer Center, was awarded a $2 million grant from NIH to investigate innovative strategies to prevent drug resistance in melanoma treatment and improve the effectiveness of MAPK inhibitors, a common treatment for patients with melanomas that carry the BRAFV600 mutation.

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