Clinical Roundup

City of Hope Children’s Cancer Center, Children’s Oncology Group conduct clinical trial seeking to prevent heart failure among pediatric cancer survivors

The largest clinical trial to date seeking to reduce the risk of people who have survived childhood cancer from developing heart failure found that carvedilol, a blood vessel relaxing medication, is safe for childhood cancer survivors and may improve important markers of heart injury sustained as a result of chemotherapy exposure.
Clinical Roundup

Phase III trial evaluating sotorasib + panitumumab: MCC patients with rare tumor mutation experienced superior PFS compared to standard of care

An international phase III clinical trial found that metastatic colorectal cancer patients with a rare genetic tumor mutation called KRAS G12C experienced superior progression-free survival rates compared to standard of care when offered a combination treatment of KRAS inhibitor sotorasib and monoclonal antibody panitumumab.