Clinical Roundup

OncoHost study offers insights into resistance mechanisms in immunotherapy-treated lung cancer

A recent OncoHost study provides insight in understanding resistance to immune checkpoint inhibitors in advanced non-small cell lung cancer. Through a comprehensive bioinformatic analysis of pretreatment plasma proteomic profiles from 272 NSCLC patients, researchers identified key biological processes associated with resistance and revealed therapeutic targets that could inform future precision treatment strategies.
Clinical Roundup

Targeted strategy prevents untreatable nerve pain caused by chemotherapy

New research out of VCU Massey Comprehensive Cancer Center is the first to suggest that a tumor-driving gene known as AEG-1 actively regulates the inflammation responsible for causing chemotherapy-induced peripheral neuropathy, a common and painful side effect of cancer treatment. Eliminating the function of this gene using targeted therapies could become a critical strategy for managing a debilitating side effect experienced by many cancer patients.
In Brief

CPRIT awards more than $93M for cancer research and prevention

On May 21, the governing body of the Cancer Prevention and Research Institute of Texas approved 61 grants totaling more than $93 million. The grants support cancer research and prevention projects across the entire spectrum of CPRIT’s mission, including CPRIT Scholar recruitment grants, a wide array of evidence-based prevention programs, and funding for early-stage companies developing promising new treatments for cancer.