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Clinical Roundup

Kisqali reduces risk of cancer recurrence for HR+/HER2- early breast cancer in phase III trial

Novartis presented positive primary endpoint data from the phase III NATALEE trial at the 2023 American Society of Clinical Oncology Annual Meeting. 
May 31, 2024
Vol.50 No.22
Drugs & Targets

Cartography, Gilead collaborate to develop therapies for breast and lung cancers

Cartography Biosciences Inc. has entered a strategic collaboration agreement with Gilead Sciences Inc., to discover and develop therapies for patients with triple-negative breast cancer and the most common form of non-small cell lung cancer, adenocarcinoma.
May 31, 2024
Vol.50 No.22
Are we focused on the wrong risk type in genetic screening?
Trials & Tribulations

Are we focused on the wrong risk type in genetic screening?
Breast cancer screening study shows new paths to population screening

A common perception of genetic screening is that only individuals at high risk of certain diseases will be identified. 
May 24, 2024
Vol.50 No.21
By Cassie Hajek
Clinical Roundup

AI tool detects possible metastatic breast cancer

Researchers at UT Southwestern Medical Center have developed a novel artificial intelligence model to improve the detection of breast cancer metastasis, which could reduce the need for needle or surgical biopsies.
May 24, 2024
Vol.50 No.21
Clinical Roundup

Orserdu combinations show favorable safety profiles for ER+, HER2- metastatic breast cancer in phase Ib/II trials

The Menarini Group and Stemline Therapeutics Inc., a wholly-owned subsidiary of the Menarini Group, will present updated results from phase Ib/II ELECTRA and ELEVATE clinical studies evaluating elacestrant (Orserdu) in combination with other treatments at the 2024 American Society of Clinical Oncology on June 2. 
May 24, 2024
Vol.50 No.21
Clinical Roundup

Vepdegestrant + Ibrance continue to show clinical benefit for ER+/HER2- breast cancer in phase Ib trial

Updated clinical data from a phase Ib combination cohort evaluating vepdegestrant, an investigational oral proteolysis targeting chimera estrogen receptor degrader, in combination with palbociclib (Ibrance) are consistent with data presented at the San Antonio Breast Cancer Symposium in December 2023.
May 24, 2024
Vol.50 No.21
Clinical Roundup

UCLA study: Combination of breast cancer and chemo may speed physical decline in older adults

Women who are 65 years old or older with high-risk breast cancer and are treated with chemotherapy are more likely to develop a substantial decline in physical function, a UCLA-led study suggests.
May 17, 2024
Vol.50 No.20
In Brief

Norman Wolmark receives American Surgical Association Medallion for Advancement of Surgical Care

Norman Wolmark, chairman of the NSABP Foundation Inc., and group chair and contact principal investigator of NRG Oncology, received the 2024 American Surgical Association Medallion for Advancement of Surgical Care at the American Surgical Association’s 144th annual meeting in Washington, DC.
May 10, 2024
Vol.50 No.19
Clinical Roundup

A nanoparticle can penetrate the blood-brain barrier and may help to treat brain metastases

When cancer breaches the brain, it can be difficult for treatment to follow.
May 10, 2024
Vol.50 No.19
USPSTF’s Wanda Nicholson: Final recommendation to start breast cancer screening at 40 will save 20% more lives
Conversation with The Cancer Letter

USPSTF’s Wanda Nicholson: Final recommendation to start breast cancer screening at 40 will save 20% more lives

All women should start screening for breast cancer at age 40, with biennial screening continuing through age 74, the U.S. Preventive Services Task Force said in its final recommendation statement April 30.
May 03, 2024
Vol.50 No.18
By Matthew Bin Han Ong

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