Alexander Price named assistant professor at Wistar

Share on facebook
Share on twitter
Share on linkedin
Share on email
Share on print
Alexander Price

Alexander Price was named assistant professor in the Gene Expression and Regulation Program of the Ellen and Ronald Caplan Cancer Center at The Wistar Institute.

Price’s research focuses on how viral genomes are controlled during infection—specifically, how viruses regulate and exploit RNA transcription and processing. His work aims to identify and exploit therapeutic targets underlying how viruses hijack cellular transcriptional machinery to combat disease.

“We are immensely pleased to welcome Alex Price to Wistar. The Institute is committed to expanding our understanding of viruses’ role in cancer as well as other disease, and the establishment of the Price Lab at Wistar represents a significant investment in the Institute’s research capacity,” Dario Altieri, Wistar president and CEO, director of the Ellen and Ronald Caplan Cancer Center, and the Robert and Penny Fox Distinguished Professor, said in a statement. “Alex’s experience in viral RNA and DNA research makes it clear that he will make compelling, fresh contributions to Wistar’s research program.”

Table of Contents

YOU MAY BE INTERESTED IN

Nan ZhangNoam AuslanderNan Zhang and Noam Auslander, the Wistar Institute assistant professors, have both received independent funding totaling $1.2 million over the next three years for cancer research projects from the V Foundation for Cancer Research. The grants are awarded to cancer researchers deemed “V Scholars” and allow Zhang and Auslander to pursue separate projects aimed at new strategies to improve the effectiveness of certain cancer therapies.
For over 50 years, scientists have been on a quest to identify which malignant mutations within the tumor allow rogue cells to break away from the primary tumor and travel through the bloodstream and lymphatic system to metastasize throughout the body. Now, new research suggests an alternative mechanism has been overlooked—elusive mutations driving metastasis may not be developing within the twisted DNA of tumors themselves, but within the patient’s regular, inherited DNA. 
The Wistar Institute’s president and CEO, Dario C. Altieri, and his team have demonstrated the role of Parkin—a protein implicated in Parkinson’s disease—in the body’s innate immune response to cancer. Parkin is not expressed in several cancers. Altieri and his team engineered cancer cells to re-express Parkin and found that Parkin contributes to the production of interferons, which activate and attract T cells to fight the tumor. The lab’s findings were published in The Journal of Clinical Investigation.

Never miss an issue!

Get alerts for our award-winning coverage in your inbox.

Login