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The Obama administration will find the money to create a comprehensive oncology bioinformatics system, Vice President Joe Biden pledged Jan. 19 at a meeting of international cancer experts at the World Economic Forum in Davos-Klosters, Switzerland.

Biden, whose son Beau died of brain cancer in May 2015 at age 46, is leading the White House “moonshot” program, which was announced by President Barack Obama during his final State of the Union address Jan. 12 (The Cancer Letter, Jan. 15).

Obama is expected to announce the details of funding the moonshot in his budget proposal Feb. 9.

	Biden: Cancer Moonshot Seeks Quantum Leaps, Not Incremental Change The text of Vice President Joe Biden’s Jan. 19 remarks at a World Economic Forum meeting of international cancer experts in Davos-Klosters, Switzerland, follows: Almost everyone in the world, as you all know, has a family member who’s had cancer. Every year, around the world, 14 million people are diagnosed with cancer and 8 million people succumb to it, die, from cancer. And like many of you, I have experienced in my family the dreaded C-word that I think is the most frightening word that most people—as these docs and scientists can tell you—that anyone wants to hear walking out of a doctor’s office.
	Guest Editorial The False Allure of The Cancer Cure By Robert Cook-Deegan Over the past century, we have had many wars on cancer, and now we have a national “moonshot” to be spearheaded by Vice President Joe Biden, announced in President Barack Obama’s Jan. 12 State of the Union Address. In 1937, even as Congress was establishing the National Cancer Institute as the first of the National Institutes of Health, the American Committee to Combat Cancer was organizing the “Women’s Field Army” to mobilize against cancer, especially uterine, ovarian, and breast cancers. The main argument was that the nation was spending vastly more per person affected, and per death, on polio than it was on cancer. It was framed as a war.
	In Brief James Willson named chief scientific officer of CPRIT Mary-Claire King wins the Szent-Györgyi Prize for Progress in Cancer Research Mylin Torres named director of Glenn Family Breast Center at Winship New York Genome Center receives $100 million grant from the Simons Foundation and Carson Family Charitable Trust MD Anderson Cancer Center and AbbVie form immuno-oncology collaboration
	Drugs and Targets Venetoclax receives Breakthrough Therapy Designation from FDA FDA grants Priority Review to lenvatinib

20160115 - Jan 15, 2016

ISSUE 2 – JAN. 15, 2016

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Obama Announces Moonshot to Cure Cancer

President Barack Obama announced a moonshot aimed at curing cancer, a project to be led by Vice President Joe Biden.

The United States can do “so much more,” Obama said in his seventh and final State of the Union address Jan. 12. “Last year, Vice President Biden said that with a new moonshot, America can cure cancer. Last month, he worked with this Congress to give scientists at the National Institutes of Health the strongest resources they’ve had over a decade.

“Tonight, I’m announcing a new national effort to get it done. And because he’s gone to the mat for all of us, on so many issues over the past 40 years, I’m putting Joe in charge of mission control. For the loved ones we’ve all lost, for the family we can still save—let’s make America the country that cures cancer once and for all.”

	When Moonshots Collide Did Patrick Soon-Shiong attempt to scoop President Barack Obama’s State of the Union address? Several days before Obama announced the federal government’s moonshot to cure cancer, Soon-Shiong put out a draft press release, claiming that the White House, NIH, FDA and pharmaceutical companies have united in “Cancer MoonShot 2020,” an immunotherapy clinical trials program he devised. Soon-Shiong, founder and CEO of NantWorks and the Chan Soon-Shiong Institute of Molecular Medicine, ultimately announced his moonshot on Jan. 11, a day before Obama announced his.
	Conversation with The Cancer Letter Soon-Shiong Says FDA & NCI are Onboard For His Moonshot; Feds Deny Involvement Government agencies said the biotechnology billionaire Patrick Soon-Shiong had overstated the extent of their involvement in “Cancer MoonShot 2020,” the immunotherapy clinical trials program he put together. In an in-depth conversation with Matthew Bin Han Ong, a reporter with The Cancer Letter, Soon-Shiong said that while his program doesn’t seek federal funds, it has the support of NCI and FDA officials. Soon-Shiong said he and Vice President Joe Biden met to discuss their interlocking missions and are now pursuing them.
	USPSTF Recommends Biennial Mammography Screening For Women Ages 50-74 The U.S. Preventive Services Task Force published its final recommendation statement on screening for breast cancer, delivering a B rating for mammography screening every two years in women between ages 50 and 74. The task force also recommended selectively offering mammography to women below age 50, saying that the decision to begin that screening should be an individual one. The USPSTF gave this age group a C recommendation. “Women who place a higher value on the potential benefit than the potential harms may choose to begin biennial screening between the ages of 40 and 49 years,” the task force wrote in its recommendations.
	Campaign for Tobacco-Free Kids Demands Recall of Gold Standard Accreditation of U.S. Chamber of Commerce The Campaign for Tobacco-Free Kids said the U.S. Chamber of Commerce is undeserving of its Gold Standard accreditation by the CEO Roundtable on Cancer, saying it should be rescinded because of the trade group’s lobbying efforts against tobacco regulations.
	In Brief Leonard Zon receives Knudsen cancer genetics award from NCI Amy McKee named acting deputy office director at FDA OHOP Paul Kluetz appointed associate director of clinical science at FDA OHOP Dean Tsarwhas named medical director at Northwestern Medicine Lake Forest Hospital Rafat Abonour named medical liaison for the International Myeloma Foundation Ravi Salgia joins City of Hope as chair of Department of Medical Oncology FASEB publishes recommendations for research reproducibility COA elects new board and executive committee members
	Drugs and Targets Blincyto receives conditional approval from Health Canada FDA grants priority review to venetoclax in CLL Sorrento Therapeutics and Karolinska Institutet form collaboration Eisai submits MAA to European Medicines Agency for lenvatinib MD Anderson and DelMar Pharmaceuticals form collaboration Debiopharm International SA collaborates in EORTC trial

20160108 - Jan 8, 2016

ISSUE 1 – JAN. 8, 2016

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Ellen Stovall, Pioneering Advocate For Survivorship, Dies at 69

Ellen Stovall, one of the most respected and knowledgeable cancer advocates in Washington, died Jan. 5.

The cause of death was a heart attack.

Stovall, 69, was first diagnosed with Hodgkin’s lymphoma in 1971. Her disease recurred in 1983. In 2007, she had bilateral mastectomies due to the late effects of the radiation treatment. Her heart disease and chronic pain were also attributed to her original treatment.

“Ellen is a rare transformational figure in cancer care, who saw an enormous unfilled need and led the development of the entire concept of cancer survivorship,” said Norman Coleman, head of the Experimental Therapeutics Section and associate director of the NCI Division of Cancer Treatment and Diagnosis, and senior medical advisor at the HHS Office of the Assistant Secretary for Preparedness and Response.

	Nobel Laureate Alfred Gilman, Defender of Good Science, Dies at 74 Alfred G. Gilman, a Nobel laureate who concluded his academic career in the role of chief scientific officer of the Cancer Prevention and Research Institute of Texas, died Dec. 23, 2015. Gilman, 74, had pancreatic cancer. Gilman shared the 1994 Nobel Prize in Physiology or Medicine with Martin Rodbell of the National Institute of Environmental Health Sciences for their discovery of G proteins—guanine nucleotide-binding regulatory proteins. G proteins are central to signaling transduction, the process of receiving signals from outside the cell and activating a range of cellular responses. G proteins are found in nearly all cells, and are central to body processes that include vision, smell, hormone secretion, and thinking in humans. Problems in G-protein signaling contribute to a range of diseases, including cholera, whooping cough, and cancer.
	Cancer Death Rate Continues Steady Drop Steady reductions in smoking combined with advances in cancer prevention, early detection, and treatment have resulted in a 23 percent drop in the cancer death rate since its peak in 1991, according to the annual Cancer Statistics report from the American Cancer Society. The drop translates to more than 1.7 million cancer deaths averted through 2012. The findings were published in CA: A Cancer Journal for Clinicians. The report estimates there will be 1,685,210 new cancer cases and 595,690 cancer deaths in the United States in 2016.
	Lab-Developed Tests AMP Responds to FDA Report On Regulation and Oversight The Association for Molecular Pathology responded to the FDA’s call for oversight of laboratory developed tests, rebutting 20 case studies published by the federal agency that illustrated possible harms inflicted on patients when laboratories did not follow FDA requirements. The AMP said the agency’s collection of case studies “grossly misrepresents the public health concerns of laboratory developed testing procedures,” and said that FDA oversight would likely prevent few of the potential patient harms. In the case of clinical trials performed at Duke University using a faulty genomics predictor to assign cancer treatment to individual patients, the AMP said that that test did not cause patient harm, and was not used in a clinical setting.
	Funding Opportunity AACR and Bayer Offering Research Grants The American Association for Cancer Research and Bayer announced the 2016 AACR-Bayer Innovation and Discovery Grants program for meritorious projects that examine novel targets and biomarkers in oncology research.
	In Brief St. Jude to open new Graduate School for Biomedical Sciences Research!America unveils 2016 policy wish list Memorial Sloan Kettering opens outpatient surgery center Inova and George Mason University form research partnership St. Jude receives $20 million commitment from Steven & Alexandra Cohen Foundation
	Drugs and Targets FDA grants Breakthrough Therapy Designation to Boehringer Ingelheim TKI Inhibitor in NSCLC Stem Cell Theranostics and CapellaBio launch collaboration on cardiotoxicity Amgen enters into agreement with GSK to reclaim rights to Prolia, XGEVA, and Vectibix

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