An independent data safety monitoring board recommended that a phase III study of zoptarelin doxorubicin in women with advanced, recurrent or metastatic endometrial cancer continue as planned, after it completed its first interim futility analysis.
Patients with metastatic stomach or esophageal cancers driven by a mutated HER2 gene had markedly improved response rates and survival when Avastin (bevacizumab) was added to a combination of capecitabine and oxaliplatin chemotherapy and Herceptin (trastuzumab).
Researchers found that patients being treated with statins at the time of surgery for renal cell carcinoma had improved overall survival and disease-specific survival.
Interim results from a global, randomized phase II study in people with previously treated non-small cell lung cancer showed that the immunotherapy MPDL3280A doubled the overall survival (HR=0.47) in people whose cancer expressed the highest levels of PD-L1 compared with docetaxel chemotherapy.
Updated long-term survival results from IMAGE 1, a phase II clinical trial evaluating a combination of IMM-101 and gemcitabine as first-line treatment for advanced pancreatic cancer, found that, in patients with metastatic disease, IMM-101 was associated with improving the probability of survival at 12 months to 24 percent, compared to 11.5 percent in patients receiving gemcitabine alone.
CHICAGO—The American Society of Clinical Oncology announced June 1 that it will move forward with its first-ever clinical trial, a study designed to offer patients with advanced cancer access to molecularly-targeted cancer drugs and to collect data on clinical outcomes to learn the best uses of these drugs outside of FDA-approved indications.
CHICAGO—NCI's long-planned, large scale precision medicine trial will open to patient enrollment in July, investigators announced June 1 at the annual meeting of the American Society of Clinical Oncology.
The European Commission approved Aloxi (palonosetron HCl) injection for the prevention of acute nausea and vomiting associated with highly emetogenic cancer chemotherapy and the prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy, in pediatric patients one month of age and older.
Halozyme Therapeutics Inc. and Ventana Medical Systems Inc., a member of the Roche Group, will collaborate and develop a Ventana companion diagnostic assay for use with Halozyme's investigational new drug PEGPH20.
The Committee for Medicinal Products for Human Use of the European Medicines Agency issued a positive opinion recommending a change to the terms of the marketing authorization for Imbruvica (ibrutinib) in the European Union to indicate the treatment of adult patients with Waldenström's macroglobulinemia who have received at least one prior therapy, or in first line treatment for patients unsuitable for chemo-immunotherapy.
