In the phase III PSMAfore trial, Pluvicto (lutetium (177Lu) vipivotide tetraxetan) met its primary endpoint with a clinically meaningful and statistically significant benefit in radiographic progression-free survival in patients with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer after treatment with androgen receptor pathway inhibitor therapy, compared to a change in ARPI1.
In the phase III ALINA study, Alecensa (alectinib) reduced the risk of disease recurrence or death by 76% (hazard ratio [HR]=0.24, 95% CI: 0.13-0.43, p<0.0001) compared with platinum-based chemotherapy in people with completely resected stage 1B (tumor ≥4 cm) to 3A (UICC/AJCC 7th edition) anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer.
Recently diagnosed cancer patients often decide on their own to visit hospital emergency departments for symptoms that don’t warrant that type of care, UT Southwestern Medical Center researchers report.
A study published in Journal of Personalized Medicine explores how oncology subspecialist reviews of pancreatic adenocarcinoma cases can identify care gaps and provide recommendations intended to improve treatment outcomes.
A research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein) on the CD95 receptor that can cause cells to die.
In exploratory analyses of results from the SWOG S1801 trial in patients with stage III-IV resectable melanoma, researchers saw a major pathologic response in more than half of surgical specimens taken from patients who had been treated with neoadjuvant Keytruda (pembrolizumab).
Results from the phase II TRUST-II trial demonstrate that taletrectinib, an investigational next-generation ROS1 inhibitor, shrank tumors (confirmed objective response rate, cORR, as assessed by an independent review committee, IRC) in 92% of patients with advanced ROS1-positive non-small cell lung cancer who had not previously been treated with a ROS1 tyrosine kinase inhibitor.
A study demonstrated that viral immune evasion enabled breakthrough infections of COVID-19 in patients with lung cancer, highlighting the importance of effective monitoring mechanisms, such as anti-N serology, to track infection rates in specific vulnerable populations.
Mount Sinai researchers have discovered a link between certain per- and polyfluoroalkyl substances and an increased risk for thyroid cancer, according to a study published in eBioMedicine.
Researchers at Keck School of Medicine of USC and USC Norris Comprehensive Cancer Center uncovered racial bias leading to recommended therapy being rejected and to delays in care, diagnosis.
