Paid

Clinical Roundup

Phase III trial evaluating sotorasib + panitumumab: MCC patients with rare tumor mutation experienced superior PFS compared to standard of care

An international phase III clinical trial found that metastatic colorectal cancer patients with a rare genetic tumor mutation called KRAS G12C experienced superior progression-free survival rates compared to standard of care when offered a combination treatment of KRAS inhibitor sotorasib and monoclonal antibody panitumumab. 
Clinical Roundup

Phase III trial of Jemperli + chemo meets endpoint of OS in primary advanced or recurrent endometrial cancer

Part 1 of the phase III RUBY trial of Jemperli (dostarlimab) plus standard-of-care chemotherapy (carboplatin and paclitaxel) followed by dostarlimab as a single agent, compared to placebo plus chemotherapy followed by placebo in adult patients with primary advanced or recurrent endometrial cancer produced positive primary results from a planned analysis.