A comprehensive RNA and DNA sequencing platform benefits late-stage and drug-resistant multiple myeloma patients by determining which drugs would work best for them, according to results from a clinical trial published in JCO Precision Oncology in August.
Researchers at Duke Cancer Institute have tracked the missing T-cells in glioblastoma patients. They found them in abundance in the bone marrow, locked away and unable to function because of a process the brain stimulates in response to glioblastoma, to other tumors that metastasize in the brain and even to injury.
Researchers at the Johns Hopkins Bloomberg—Kimmel Institute for Cancer Immunotherapy developed a new way to use bioinformatics as a gathering tool to determine how a patient's immune system responds to immunotherapy and recognizes its own tumor.
The National Comprehensive Cancer Network has released new treatment guidelines for a group of rare cancers that impact women during pregnancy. Gestational trophoblastic neoplasia, also known as gestational trophoblastic disease, can occur when tumors develop in the cells that would normally form the placenta during pregnancy.
A cache of brain cancer biomedical data has been made freely available to researchers worldwide, say researchers at Georgetown Lombardi Comprehensive Cancer Center. The dataset, Repository for Molecular Brain Neoplasia Data, also known as REMBRANDT, hosted and supported by Georgetown, is one of only two such large collections in the country.
Almost one year after FDA approval of chimeric antigen receptor T-cell therapy for children with acute lymphoblastic leukemia, researchers at MD Anderson Cancer Center and the Pediatric Acute Lung Injury and Sepsis Investigators Network published treatment guidelines for managing the treatment in the online issue of Nature Reviews Clinical Oncology.
In the first such clinical trial in the United States, physician-scientists with the University of Maryland School of Medicine are investigating the use of MRI-guided focused ultrasound to open the blood-brain barrier. The trial will be conducted with patients undergoing brain cancer surgery at the University of Maryland Medical Center.
Researchers at UC Davis, Genentech, and Foundation Medicine are the first to show that a blood-based test to assess tumor mutational burden accurately identifies non-small cell lung cancer patients who could benefit from immunotherapies called checkpoint inhibitors.
A study in the Journal of the National Cancer Institute has identified specific genes associated with increased risk for triple-negative breast cancer, providing the basis for better risk management.
The global age-standardized lung cancer mortality rate among women is projected to increase by 43 percent from 2015 to 2030, according to an analysis of data from 52 countries. The global age-standardized breast cancer mortality rate is projected to decrease by 9 percent in the same time frame. The data was published in Cancer Research.
