Clinical Roundup

Clinical Roundup

KEYNOTE-775 study shows Keytruda + Lenvima improves survival in advanced endometrial carcinoma

Results from the pivotal phase III KEYNOTE-775/Study 309 trial, evaluating the combination of Keytruda (pembrolizumab) plus Lenvima (lenvatinib) versus chemotherapy (treatment of physician’s choice of doxorubicin or paclitaxel) for patients with advanced endometrial carcinoma following at least one prior platinum-based regimen in any setting, showed the combination led to significantly longer progression-free survival and overall survival. 
Clinical Roundup

Imfinzi + tremelimumab improves OS in first-line unresectable HCC, with 31% of patients alive at three years

Positive results from the HIMALAYA phase III trial showed a single priming dose of tremelimumab added to Imfinzi (durvalumab) demonstrated a statistically significant and clinically meaningful improvement in overall survival versus Nexavar (sorafenib) as a first-line treatment for patients with unresectable hepatocellular carcinoma who had not received prior systemic therapy and were not eligible for localized treatment.